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Comparative and Functional Genomics
Volume 4, Issue 4, Pages 410-415
http://dx.doi.org/10.1002/cfg.310
Conference Review

Understanding and Predicting Protein Assemblies with 3D Structures

EMBL, Meyerhofstrasse 1, Heidelberg D69117, Germany

Received 22 May 2003; Revised 3 June 2003; Accepted 3 June 2003

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Protein interactions are central to most biological processes, and are currently the subject of great interest. Yet despite the many recently developed methods for interaction discovery, little attention has been paid to one of the best sources of data: complexes of known three-dimensional (3D) structure. Here we discuss how such complexes can be used to study and predict protein interactions and complexes, and to interrogate interaction networks proposed by methods such as two-hybrid screens or affinity purifications.