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Comparative and Functional Genomics
Volume 4, Issue 3, Pages 337-341
http://dx.doi.org/10.1002/cfg.287
Short communication

Mapping Functional Associations in the Entire Genome of Drosophila melanogaster Using Fusion Analysis

1INA-EKETA, Thessaloniki GR-57001, Greece
2Computational Biology Center, Memorial Sloan–Kettering Cancer Center, New York, NY 10021, USA
3Institut Curie, Paris F-75248, France
4Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK

Received 10 July 2002; Revised 17 February 2003; Accepted 17 February 2003

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We have previously shown that the detection of gene fusion events can contribute towards the elucidation of functional associations of proteins within entire genomes. Here we have analysed the entire genome of Drosophila melanogaster using fusion analysis and two additional constraints that improve the reliability of the predictions, viz. low sequence similarity and low degree of paralogy of the component proteins involved in a fusion event. Imposing these constraints, the total number of unique component pairs is reduced from 18 654 to a mere 220 cases, which are expected to represent some of the most reliably detected functionally associated proteins. Using additional information from sequence databases, we have been able to detect pairs of functionally associated proteins with important functions in cellular and developmental pathways, such as spermatogenesis and programmed cell death.