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Comparative and Functional Genomics
Volume 5, Issue 8, Pages 633-641
Conference paper

Standardization Initiatives in the (eco)toxicogenomics Domain: A Review

1EMBL-EBI, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, United Kingdom
2The University of Manchester, Kilburn Building, School of Computer Science, Oxford Road, Manchester M13 9PL, United Kingdom
3National Institute of Environmental Health Sciences, National Center for Toxicogenomics. Research Triangle Park, NC 27709, USA

Revised 24 November 2004; Accepted 26 November 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this document is to provide readers with a resource of different ongoing standardization efforts within the ‘omics’ (genomic, proteomics, metabolomics) and related communities, with particular focus on toxicological and environmental applications. The review includes initiatives within the research community as well as in the regulatory arena. It addresses data management issues (format and reporting structures for the exchange of information) and database interoperability, highlighting key objectives, target audience and participants. A considerable amount of work still needs to be done and, ideally, collaboration should be optimized and duplication and incompatibility should be avoided where possible. The consequence of failing to deliver data standards is an escalation in the burden and cost of data management tasks.