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Comparative and Functional Genomics
Volume 5, Issue 2, Pages 196-200
http://dx.doi.org/10.1002/cfg.378
Conference review

Looking for Cancer Clues in Publicly Accessible Databases

1Laboratory of Molecular Technology, SAIC–Frederick, National Cancer Institute at Frederick, PO Box B, 915 Tollhouse Avenue, Suite 211, Frederick, MD 21701, USA
2Science Applications International Corporation, Frederick, MD, USA

Received 10 November 2003; Revised 12 December 2003; Accepted 18 December 2003

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

What started out as a mere attempt to tentatively identify proteins in experimental cancer-related 2D-PAGE maps developed into VIRTUAL2D, a web-accessible repository for theoretical pI/MW charts for 92 organisms. Using publicly available expression data, we developed a collection of tissue-specific plots based on differential gene expression between normal and diseased states. We use this comparative cancer proteomics knowledge base, known as the tissue molecular anatomy project (TMAP), to uncover threads of cancer markers common to several types of cancer and to relate this information to established biological pathways.