Frequency of Cancer Genes on the Chicken Z  Chromosome and Its Human Homologues: Implications  for Sex  Chromosome Evolution

Stiglec, Rami; Kohn, Matthias; Fong, James; Ezaz, Tariq; Hameister, Horst; Marshall Graves, Jennifer A.

doi:https://doi.org/10.1155/2007/43070

International Journal of Genomics

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Research Article | Open Access

Volume 2007 | Article ID 043070 | https://doi.org/10.1155/2007/43070

Frequency of Cancer Genes on the Chicken Z Chromosome and Its Human Homologues: Implications for Sex Chromosome Evolution

Rami Stiglec,¹Matthias Kohn,²James Fong,¹Tariq Ezaz,¹Horst Hameister,²and Jennifer A. Marshall Graves¹

Academic Editor: Peter Little

Received31 May 2006

Revised27 Oct 2006

Accepted19 Nov 2006

Published04 Jan 2007

Abstract

It has been suggested that there are special evolutionary forces that act on sex chromosomes. Hemizygosity of the X chromosome in male mammals has led to selection for male-advantage genes, and against genes posing extreme risks of tumor development. A similar bias against cancer genes should also apply to the Z chromosome that is present as a single copy in female birds. Using comparative database analysis, we found that there was no significant underrepresentation of cancer genes on the chicken Z, nor on the Z-orthologous regions of human chromosomes 5 and 9. This result does not support the hypothesis that genes involved in cancer are selected against on the sex chromosomes.

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Copyright

Copyright © 2007 Rami Stiglec et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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