Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order

Table 1

Membrane transport systems found in the O. tsutsugamushi genome.

Transporter type	Gene/CDS			Putative substrate
ATP dependant (ABC family)	ABC	Membrane	Binding protein
			yqiX: OTBS_0447	Amino acid
		yqiY: OTBS_0224		Glutamine
	glnQ: OTBS_0223			Glutamine
	mkI: OTBS_0496	yrbE: OTBS_0495	yrbD: OTBS_1584	Toluene tolerance
	znuC: OTBS_1910	znuB: OTBS_1909	znuA:OTBS_0441	Zinc, manganese
	ccmA: OTBS_1392	ccmB: OTBS_1393		Heme
		ccmC: OTBS_1577		Heme
		msbA1: OTBS_0552^*		Multidrug
		msbA2: OTBS_0995^*		Multidrug
		aprD: OTBS_0305^*		Alkaliine protease
	abcZ: OTBS_0269
		abcT3: OTBS_0695^*
	abcT1: OTBS_0781
Ion channels	OTBS_1945			Mechanosensitive ion
Secondary transporter	tlc: OTBS_0312, OTBS_0313,			ATP/ADP antiporter
	OTBS_0547, OTBS_1035, OTBS_1636
	OTBS_1312, OTBS_0017?			Malate
	atrC1: OTBS_1417			Cationic aminio acid
	potE: OTBS_1403			Arginine/orinithine
	p34: OTBS_1715			Cation
	kefB: OTBS_1539			Potassium
	gltP: OTBS_0443			Proton/glutamate
	rarD: OTBS_0203, OTBS_0407?			S-adenosylmethionine
	proP: OTBS_0158, OTBS_0204,			Proline/betaine
	OTBS_0844, OTBS_1493, OTBS_1955
	panF: OTBS_0515, OTBS_1379,			Na^+/proline symporter
	ampG: OTBS_0516			Muropeptide
	bcr: OTBS_1499, OTBS_1891			Multidurg
	mnhE: OTBS_0147, mnhG: OTBS_1421,			Na^+/H^+ antiporter
	mbhE: OTBS_1422
	mnhB: OTBS_1423, mnhC: OTBS_1424			(multisubunit antiporter)
Unclassified	mgtE: OTBS_0470			Magnesium
	OTBS_0219?			iron

^*Contains both an ABC and a membrane domain as one polypeptide.