Classification of Nonenzymatic Homologues of Protein Kinases

Table 6

List of 82 PKLNKs identified from human, mouse, rat, and drosophila. Their gene accession code and domain architecture are also provided. Abbreviations followed in the table are SH2, Src homology 2; PKLNK, Protein kinase-like nonkinase, Pkinase, Protein kinase; Guanylate_cyc, Guanylate cyclase; TM, Transmembrane; Ank, Ankyrin; SAM, Sterile alpha motif; PX, Phox; I-set, Immunoglobulin; fn3, Fibronectin type III; Ephrin_lbd, Ephrin receptor ligand binding domain.

Gene accession code	Domain name, boundary, and E-value
ENSP00000222246	SH2, 377 457 0.0066 * PKLNK, 822 1071 2e-27 *
ENSP00000264818	PKLNK, 589 866 4.9e-10 * Pkinase, 897 1172 1.2e-44 *
ENSP00000294423	SH2, 441 526 0.0016 * PKLNK, 583 847 1e-12 * Pkinase, 877 1151 2.1e-40 *
ENSP00000371067	SH2, 401 481 0.00012 * PKLNK, 545 805 2.6e-10 * Pkinase, 849 1123 4.4e-42 *
gi|109476840|ref|XP_001061647.1|	SH2, 486 570 0.0016 * PKLNK, 627 889 1.5e-12 * Pkinase, 919 1193 3.5e-39 *
gi|111607496|ref|NP_666257.2|	SH2, 441 525 0.0038 * PKLNK, 582 844 1.8e-12 * Pkinase, 874 1148 4.5e-39 *
gi|113194917|gb|AAF51744.3|	PKLNK, 444 650 2.4e-21 *
gi|114326478|ref|NP_001041642.1|	SH2, 401 481 0.00014 * PKLNK, 545 805 1.5e-09 * Pkinase, 849 1123 5.2e-43 *
gi|115430241|ref|NP_065731.3|	PKLNK, 29 259 4e-88 * HEAT, 383 419 0.0067 * HEAT, 501 537 3.2e-05 *
gi|119534|sp|P21860.1|ERBB3_HUMAN	Recep_L_domain, 55 167 6.7e-45 * Furin-like, 180 332 3.4e-79 * Recep_L_domain, 353 474 3.4e-46 * TM, o644 666i * PKLNK, 709 965 1.9e-24 *
gi|12052916|emb|CAB66632.1|	PKLNK, 24 258 2.2e-38 *
gi|12839087|dbj|BAB24429.1|	PKLNK, 25 289 6e-55 *
gi|12858445|dbj|BAB31320.1|	PKLNK, 195 461 5e-11 *
gi|12963867|ref|NP_076401.1|	PKLNK, 29 301 0.00098 * HEAT, 383 419 0.014 * HEAT, 501 537 0.00015 *
gi|13027388|ref|NP_061041.2|	PKLNK, 58 369 2e-28 *
gi|13027458|ref|NP_076490.1|	PKLNK, 24 286 9.9e-70 *
gi|13242283|ref|NP_077356.1|	ANF_receptor, 75 411 5.3e-59 * TM, o468 490i * PKLNK, 520 808 1.8e-09 * Guanylate_cyc, 874 1061 2.2e-92 *
gi|133922607|ref|NP_061263.2|	PKLNK, 589 863 1.7e-10 * Pkinase, 894 1166 4.5e-43 *
gi|134152694|ref|NP_001513.2|	ANF_receptor, 71 412 3.1e-83 * TM, o468 490i * PKLNK, 532 809 3.1e-14 * Guanylate_cyc, 875 1062 3.4e-92 *
gi|14041796|dbj|BAB55454.1|	PKLNK 29 259 9e-89 * HEAT, 383 419 0.0067 * HEAT, 501 537 3.2e-05 *
gi|14042287|dbj|BAB55185.1|	PKLNK, 81 327 3.2e-08 *
gi|149044565|gb|EDL97824.1|	SH2, 441 525 0.0016 * PKLNK, 582 844 1.5e-12 * Pkinase, 874 1148 3.5e-39 *
gi|156630890|sp|Q62137.2|JAK3_MOUSE	PKLNK, 818 1091 2.1e-37 *
gi|15779207|gb|AAH14662.1|	PKLNK, 18 245 0.00017 *
gi|58635954|ref|NP_113563.2|	Ank, 55 87 0.00011 * Ank, 88 120 0.018 * PKLNK, 251 503 2e-06 *
gi|159110415|ref|NP_032218.2|	ANF_receptor, 75 411 1.1e-56 * TM, o345 364i * PKLNK, 520 811 2.3e-09 * Guanylate_cyc, 874 1061 7e-92 *
gi|16306492|ref|NP_203698.1|	PKLNK, 4 230 8.7e-56 *
gi|16758684|ref|NP_446283.1|	ANF_receptor, 71 412 2.8e-74 * TM, o468 490i * PKLNK, 532 809 8.6e-11 * Guanylate_cyc, 875 1062 2.2e-92 *
gi|16758694|ref|NP_446290.1|	ANF_receptor, 44 400 5.9e-75 * TM, o456 478i * PKLNK, 534 786 5.3e-17 * Guanylate_cyc, 852 1038 5.6e-107 *
gi|17368346|sp|P83097|WSCK_DROME	TM, i12 34o * WSC, 42 115 3.8e-25 * fn3, 129 233 2e-05 * TM, o422 444i * PKLNK, 511 768 2.6e-10 *
gi|17368698|sp|Q9BXU1|STK31_HUMAN	TUDOR, 28 147 2e-31 * PKLNK, 739 972 3.6e-05 *
gi|17862032|gb|AAL39493.1|	PKLNK, 10 298 3.7e-11 *
gi|18386335|gb|AAB19934.2|	ANF_receptor, 53 386 3.9e-32 * TM, o432 454i * PKLNK, 497 745 1.1e-09 * Guanylate_cyc, 815 1002 1.5e-104 *
gi|18543337|ref|NP_570093.1|	ANF_receptor, 88 422 7e-71 * TM, o480 502i * PKLNK, 550 818 2.4e-11 * Guanylate_cyc, 884 1071 1.4e-90 *
gi|18676872|dbj|BAB85045.1|	PKLNK, 26 273 3.4e-18 * TBC, 463 673 1.1e-10 * Rhodanese, 776 883 9.2e-09 *
gi|19173772|ref|NP_596900.1|	Ank, 33 65 9.4e-09 * Ank, 66 98 1.6e-09 * Ank, 99 131 3.2e-07 * PKLNK, 193 449 1.5e-10 *
gi|20349229|ref|XP_111982.1|	PKLNK, 1 214 2e-08 * Guanylate_cyc, 306 521 1.2e-79 *
gi|204270|gb|AAA41202.1|	ANF_receptor, 50 412 1.3e-80 * PKLNK, 534 797 8.4e-13 * Guanylate_cyc, 863 1049 6e-109 *
gi|20826487|ref|XP_131378.1|	PKLNK, 1 216 7e-09 * Guanylate_cyc, 282 468 5.6e-107 *
gi|20829352|ref|XP_129532.1|	PKLNK, 18 245 8.9e-05 *
gi|20869393|ref|XP_127567.1|	PX, 17 122 2.4e-19 * PKLNK, 146 443 0.0012 *
gi|20895826|ref|XP_139682.1|	PKLNK, 4 206 3.7e-06 *
gi|21357711|ref|NP_647767.1|	PKLNK, 406 658 0.0018 *
gi|21358011|ref|NP_651655.1|	PKLNK, 31 314 5.7e-09 *
gi|21594381|gb|AAH31924.1|	TM, i13 32o * Ephrin_lbd, 34 227 4.5e-113 * fn3, 365 463 1.8e-06 * fn3, 481 565 1.3e-17 * TM, o590 612i * PKLNK, 663 908 7.4e-22 * SAM, 938 1005 1.6e-22 *
gi|21626698|gb|AAF47134.2|	I-set, 2 87 2.1e-06 * I-set, 102 195 6.9e-17 * I-set, 203 278 0.00011 * I-set, 292 382 7.6e-23 * I-set, 385 479 2.6e-05 * I-set, 483 574 2.6e-15 * I-set, 578 669 6.2e-11 * I-set, 673 765 7.1e-20 * I-set, 800 884 3.1e-10 * I-set, 893 993 0.00015 * I-set, 997 1087 2.5e-10 * I-set, 1092 1194 1.3e-05 * I-set, 1199 1290 2.1e-21 * I-set, 1297 1387 7.4e-24 * I-set, 1394 1485 7.3e-23 * I-set, 1498 1587 4.6e-21 * I-set, 1594 1683 1.1e-18 * I-set, 1696 1786 1.1e-21 * fn3, 1812 1898 9.9e-07 * I-set, 1951 2042 0.00043 * I-set, 2046 2136 7.1e-12 * PKLNK, 2165 2419 2.5e-48 * I-set, 2633 2723 1.2e-17 * fn3, 2727 2809 1.2e-12 * PKLNK, 2876 3130 1.7e-34 *
gi|21627748|gb|AAM68879.1|	PX, 17 122 7.9e-15 * PKLNK, 146 435 0.00023 *
gi|21703091|gb|AAM74471.1|	PKLNK, 145 439 e-128 *
gi|21704242|ref|NP_663596.1|	PKLNK, 24 286 3.4e-70 *
gi|21707860|gb|AAH34064.1|	TM, o114 136i * PKLNK, 176 426 3.7e-10 *Guanylate_cyc, 496 683 2e-99 *
gi|22749323|ref|NP_689862.1|	PKLNK, 209 466 1e-13 *
gi|22760572|dbj|BAC11248.1|	PKLNK, 24 286 7.8e-67 *
gi|22760645|dbj|BAC11278.1|	PKLNK, 24 286 3.4e-70 *
gi|2288925|emb|CAA04187.1|	SH2, 313 397 0.00056 * PKLNK, 454 716 3.2e-14 *
gi|22945875|gb|AAN10635.1|AE003618_7	PKLNK, 304 520 *
gi|23093524|gb|AAN11824.1|AE003537_3	ANF_receptor, 64 447 8e-33 * PKLNK, 610 869 4.4e-16 * Guanylate_cyc, 935 1121 1.5e-89 *
gi|23171402|gb|AAF55244.2|	ANF_receptor, 107 473 1.2e-83 * PKLNK, 608 877 1.8e-15 * Guanylate_cyc, 944 1130 9.7e-103 *
gi|24667933|ref|NP_525001.2|	Ank, 33 65 1.6e-07 * Ank, 66 98 1.4e-06 * Ank, 99 131 1.5e-08 * PKLNK, 192 446 6.9e-09 *
gi|2499669|sp|Q62689.1|JAK2_RAT	SH2, 401 481 8.6e-05 * PKLNK, 545 805 8.9e-10 * Pkinase, 849 1123 1.9e-43 *
gi|2499671|sp|Q63272.1|JAK3_RAT	PKLNK, 818 1091 2.7e-38 *
gi|28380344|gb|AAF53079.3|	ANF_receptor, 57 398 2e-37 * PKLNK, 529 798 3e-11 * Guanylate_cyc, 864 1050 3.3e-88 *
gi|28529710|ref|XP_142224.2|	ANF_receptor, 166 499 3.7e-62 * PKLNK, 647 926 1.5e-10 * Guanylate_cyc, 1018 1229 2.4e-72 *
gi|28804246|emb|CAD29448.2|	Death, 26 106 5.1e-18 * PKLNK, 178 456 1e-17 *
gi|31982929|ref|NP_057524.2|	PKLNK, 202 460 0.0082 *
gi|34191428|gb|AAH36504.2|	PKLNK, 48 317 7.9e-14 *
gi|40254426|ref|NP_000897.2|	ANF_receptor, 54 416 2.7e-79 * PKLNK, 538 801 3.7e-11 * Guanylate_cyc, 867 1053 7e-110 *
gi|4504217|ref|NP_000171.1|	ANF_receptor, 72 408 1.3e-55 * TM, o465 487i* PKLNK, 517 805 8.8e-10 * HNOBA, 718 870 0.009 * Guanylate_cyc, 871 1058 1.8e-89 *
gi|45446806|gb|AAF45995.2|	PKLNK, 18 263 1.2e-07 * TBC, 430 636 1.4e-08 *
gi|4580422|ref|NP_003986.2|	ANF_receptor, 44 400 2.7e-75 * PKLNK, 534 786 3.2e-18 * Guanylate_cyc, 852 1038 5.6e-107 *
gi|4758292|ref|NP_004436.1|	Ephrin_lbd, 18 217 4.5e-110 * fn3, 355 455 1.8e-06 * fn3, 473 557 3.2e-18 * TM, o582 604i * PKLNK, 655 900 1.1e-22 * SAM, 930 997 6e-22 *
gi|4758606|ref|NP_004508.1|	Ank, 33 65 9.4e-09 * Ank, 66 98 1.6e-09 * Ank, 99 131 3.2e-07 * PKLNK, 193 449 1.3e-10 *
gi|477540|pir||A49183	PKLNK, 16 250 7.9e-07 *
gi|5052670|gb|AAD38665.1|AF145690_1	PKLNK, 122 375 4.7e-09 *
gi|57997202|emb|CAD38856.2|	Ank, 55 87 0.0025 * Ank, 88 120 0.0056 * PKLNK, 251 503 1.6e-06 *
gi|58530886|ref|NP_001561.3|	Death, 14 94 2.9e-16 * PKLNK, 210 496 2.6e-11 *
gi|6005792|ref|NP_009130.1|	Death, 26 106 4.4e-18 * PKLNK, 165 443 3e-12 *
gi|7020363|dbj|BAA91097.1|	PX, 17 122 1.3e-16 * PKLNK, 146 449 0.0028 *
gi|7243101|dbj|BAA92598.1|	PKLNK, 4 190 2e-63 *
gi|7291217|gb|AAF46649.1|	ANF_receptor, 107 481 1.4e-73 * PKLNK, 555 794 3.9e-10 * Guanylate_cyc, 860 1046 1.2e-99 *
gi|7294467|gb|AAF49811.1|	ANF_receptor, 64 423 3.9e-35 * PKLNK, 573 832 4.4e-16 * Guanylate_cyc, 898 1084 1.5e-89 *
gi|7301824|gb|AAF56933.1|	PKLNK, 28 268 2e-82 * HEAT, 383 419 0.0027 *
gi|24641273	PKLNK, 892 1151 1.4e-35 *