International Journal of Genomics / 2009 / Article / Tab 6

Research Article

Classification of Nonenzymatic Homologues of Protein Kinases

Table 6

List of 82 PKLNKs identified from human, mouse, rat, and drosophila. Their gene accession code and domain architecture are also provided. Abbreviations followed in the table are SH2, Src homology 2; PKLNK, Protein kinase-like nonkinase, Pkinase, Protein kinase; Guanylate_cyc, Guanylate cyclase; TM, Transmembrane; Ank, Ankyrin; SAM, Sterile alpha motif; PX, Phox; I-set, Immunoglobulin; fn3, Fibronectin type III; Ephrin_lbd, Ephrin receptor ligand binding domain.

Gene accession codeDomain name, boundary, and E-value

ENSP00000222246 SH2, 377 457 0.0066 * PKLNK, 822 1071 2e-27 *
ENSP00000264818 PKLNK, 589 866 4.9e-10 * Pkinase, 897 1172 1.2e-44 *
ENSP00000294423 SH2, 441 526 0.0016 * PKLNK, 583 847 1e-12 * Pkinase, 877 1151 2.1e-40 *
ENSP00000371067 SH2, 401 481 0.00012 * PKLNK, 545 805 2.6e-10 * Pkinase, 849 1123 4.4e-42 *
gi 109476840 ref XP_001061647.1 SH2, 486 570 0.0016 * PKLNK, 627 889 1.5e-12 * Pkinase, 919 1193 3.5e-39 *
gi 111607496 ref NP_666257.2 SH2, 441 525 0.0038 * PKLNK, 582 844 1.8e-12 * Pkinase, 874 1148 4.5e-39 *
gi 113194917 gb AAF51744.3 PKLNK, 444 650 2.4e-21 *
gi 114326478 ref NP_001041642.1 SH2, 401 481 0.00014 * PKLNK, 545 805 1.5e-09 * Pkinase, 849 1123 5.2e-43 *
gi 115430241 ref NP_065731.3 PKLNK, 29 259 4e-88 * HEAT, 383 419 0.0067 * HEAT, 501 537 3.2e-05 *
gi 119534 sp P21860.1 ERBB3_HUMAN Recep_L_domain, 55 167 6.7e-45 * Furin-like, 180 332 3.4e-79 * Recep_L_domain, 353 474 3.4e-46 * TM, o644 666i * PKLNK, 709 965 1.9e-24 *
gi 12052916 emb CAB66632.1 PKLNK, 24 258 2.2e-38 *
gi 12839087 dbj BAB24429.1 PKLNK, 25 289 6e-55 *
gi 12858445 dbj BAB31320.1 PKLNK, 195 461 5e-11 *
gi 12963867 ref NP_076401.1 PKLNK, 29 301 0.00098 * HEAT, 383 419 0.014 * HEAT, 501 537 0.00015 *
gi 13027388 ref NP_061041.2 PKLNK, 58 369 2e-28 *
gi 13027458 ref NP_076490.1 PKLNK, 24 286 9.9e-70 *
gi 13242283 ref NP_077356.1 ANF_receptor, 75 411 5.3e-59 * TM, o468 490i * PKLNK, 520 808 1.8e-09 * Guanylate_cyc, 874 1061 2.2e-92 *
gi 133922607 ref NP_061263.2 PKLNK, 589 863 1.7e-10 * Pkinase, 894 1166 4.5e-43 *
gi 134152694 ref NP_001513.2 ANF_receptor, 71 412 3.1e-83 * TM, o468 490i * PKLNK, 532 809 3.1e-14 * Guanylate_cyc, 875 1062 3.4e-92 *
gi 14041796 dbj BAB55454.1 PKLNK 29 259 9e-89 * HEAT, 383 419 0.0067 * HEAT, 501 537 3.2e-05 *
gi 14042287 dbj BAB55185.1 PKLNK, 81 327 3.2e-08 *
gi 149044565 gb EDL97824.1 SH2, 441 525 0.0016 * PKLNK, 582 844 1.5e-12 * Pkinase, 874 1148 3.5e-39 *
gi 156630890 sp Q62137.2 JAK3_MOUSE PKLNK, 818 1091 2.1e-37 *
gi 15779207 gb AAH14662.1 PKLNK, 18 245 0.00017 *
gi 58635954 ref NP_113563.2 Ank, 55 87 0.00011 * Ank, 88 120 0.018 * PKLNK, 251 503 2e-06 *
gi 159110415 ref NP_032218.2 ANF_receptor, 75 411 1.1e-56 * TM, o345 364i * PKLNK, 520 811 2.3e-09 * Guanylate_cyc, 874 1061 7e-92 *
gi 16306492 ref NP_203698.1 PKLNK, 4 230 8.7e-56 *
gi 16758684 ref NP_446283.1 ANF_receptor, 71 412 2.8e-74 * TM, o468 490i * PKLNK, 532 809 8.6e-11 * Guanylate_cyc, 875 1062 2.2e-92 *
gi 16758694 ref NP_446290.1 ANF_receptor, 44 400 5.9e-75 * TM, o456 478i * PKLNK, 534 786 5.3e-17 * Guanylate_cyc, 852 1038 5.6e-107 *
gi 17368346 sp P83097 WSCK_DROME TM, i12 34o * WSC, 42 115 3.8e-25 * fn3, 129 233 2e-05 * TM, o422 444i * PKLNK, 511 768 2.6e-10 *
gi 17368698 sp Q9BXU1 STK31_HUMAN TUDOR, 28 147 2e-31 * PKLNK, 739 972 3.6e-05 *
gi 17862032 gb AAL39493.1 PKLNK, 10 298 3.7e-11 *
gi 18386335 gb AAB19934.2 ANF_receptor, 53 386 3.9e-32 * TM, o432 454i * PKLNK, 497 745 1.1e-09 * Guanylate_cyc, 815 1002 1.5e-104 *
gi 18543337 ref NP_570093.1 ANF_receptor, 88 422 7e-71 * TM, o480 502i * PKLNK, 550 818 2.4e-11 * Guanylate_cyc, 884 1071 1.4e-90 *
gi 18676872 dbj BAB85045.1 PKLNK, 26 273 3.4e-18 * TBC, 463 673 1.1e-10 * Rhodanese, 776 883 9.2e-09 *
gi 19173772 ref NP_596900.1 Ank, 33 65 9.4e-09 * Ank, 66 98 1.6e-09 * Ank, 99 131 3.2e-07 * PKLNK, 193 449 1.5e-10 *
gi 20349229 ref XP_111982.1 PKLNK, 1 214 2e-08 * Guanylate_cyc, 306 521 1.2e-79 *
gi 204270 gb AAA41202.1 ANF_receptor, 50 412 1.3e-80 * PKLNK, 534 797 8.4e-13 * Guanylate_cyc, 863 1049 6e-109 *
gi 20826487 ref XP_131378.1 PKLNK, 1 216 7e-09 * Guanylate_cyc, 282 468 5.6e-107 *
gi 20829352 ref XP_129532.1 PKLNK, 18 245 8.9e-05 *
gi 20869393 ref XP_127567.1 PX, 17 122 2.4e-19 * PKLNK, 146 443 0.0012 *
gi 20895826 ref XP_139682.1 PKLNK, 4 206 3.7e-06 *
gi 21357711 ref NP_647767.1 PKLNK, 406 658 0.0018 *
gi 21358011 ref NP_651655.1 PKLNK, 31 314 5.7e-09 *
gi 21594381 gb AAH31924.1 TM, i13 32o * Ephrin_lbd, 34 227 4.5e-113 * fn3, 365 463 1.8e-06 * fn3, 481 565 1.3e-17 * TM, o590 612i * PKLNK, 663 908 7.4e-22 * SAM, 938 1005 1.6e-22 *
gi 21626698 gb AAF47134.2 I-set, 2 87 2.1e-06 * I-set, 102 195 6.9e-17 * I-set, 203 278 0.00011 * I-set, 292 382 7.6e-23 * I-set, 385 479 2.6e-05 * I-set, 483 574 2.6e-15 * I-set, 578 669 6.2e-11 * I-set, 673 765 7.1e-20 * I-set, 800 884 3.1e-10 * I-set, 893 993 0.00015 * I-set, 997 1087 2.5e-10 * I-set, 1092 1194 1.3e-05 * I-set, 1199 1290 2.1e-21 * I-set, 1297 1387 7.4e-24 * I-set, 1394 1485 7.3e-23 * I-set, 1498 1587 4.6e-21 * I-set, 1594 1683 1.1e-18 * I-set, 1696 1786 1.1e-21 * fn3, 1812 1898 9.9e-07 * I-set, 1951 2042 0.00043 * I-set, 2046 2136 7.1e-12 * PKLNK, 2165 2419 2.5e-48 * I-set, 2633 2723 1.2e-17 * fn3, 2727 2809 1.2e-12 * PKLNK, 2876 3130 1.7e-34 *
gi 21627748 gb AAM68879.1 PX, 17 122 7.9e-15 * PKLNK, 146 435 0.00023 *
gi 21703091 gb AAM74471.1 PKLNK, 145 439 e-128 *
gi 21704242 ref NP_663596.1 PKLNK, 24 286 3.4e-70 *
gi 21707860 gb AAH34064.1 TM, o114 136i * PKLNK, 176 426 3.7e-10 *Guanylate_cyc, 496 683 2e-99 *
gi 22749323 ref NP_689862.1 PKLNK, 209 466 1e-13 *
gi 22760572 dbj BAC11248.1 PKLNK, 24 286 7.8e-67 *
gi 22760645 dbj BAC11278.1 PKLNK, 24 286 3.4e-70 *
gi 2288925 emb CAA04187.1 SH2, 313 397 0.00056 * PKLNK, 454 716 3.2e-14 *
gi 22945875 gb AAN10635.1 AE003618_7 PKLNK, 304 520 *
gi 23093524 gb AAN11824.1 AE003537_3 ANF_receptor, 64 447 8e-33 * PKLNK, 610 869 4.4e-16 * Guanylate_cyc, 935 1121 1.5e-89 *
gi 23171402 gb AAF55244.2 ANF_receptor, 107 473 1.2e-83 * PKLNK, 608 877 1.8e-15 * Guanylate_cyc, 944 1130 9.7e-103 *
gi 24667933 ref NP_525001.2 Ank, 33 65 1.6e-07 * Ank, 66 98 1.4e-06 * Ank, 99 131 1.5e-08 * PKLNK, 192 446 6.9e-09 *
gi 2499669 sp Q62689.1 JAK2_RAT SH2, 401 481 8.6e-05 * PKLNK, 545 805 8.9e-10 * Pkinase, 849 1123 1.9e-43 *
gi 2499671 sp Q63272.1 JAK3_RAT PKLNK, 818 1091 2.7e-38 *
gi 28380344 gb AAF53079.3 ANF_receptor, 57 398 2e-37 * PKLNK, 529 798 3e-11 * Guanylate_cyc, 864 1050 3.3e-88 *
gi 28529710 ref XP_142224.2 ANF_receptor, 166 499 3.7e-62 * PKLNK, 647 926 1.5e-10 * Guanylate_cyc, 1018 1229 2.4e-72 *
gi 28804246 emb CAD29448.2 Death, 26 106 5.1e-18 * PKLNK, 178 456 1e-17 *
gi 31982929 ref NP_057524.2 PKLNK, 202 460 0.0082 *
gi 34191428 gb AAH36504.2 PKLNK, 48 317 7.9e-14 *
gi 40254426 ref NP_000897.2 ANF_receptor, 54 416 2.7e-79 * PKLNK, 538 801 3.7e-11 * Guanylate_cyc, 867 1053 7e-110 *
gi 4504217 ref NP_000171.1 ANF_receptor, 72 408 1.3e-55 * TM, o465 487i* PKLNK, 517 805 8.8e-10 * HNOBA, 718 870 0.009 * Guanylate_cyc, 871 1058 1.8e-89 *
gi 45446806 gb AAF45995.2 PKLNK, 18 263 1.2e-07 * TBC, 430 636 1.4e-08 *
gi 4580422 ref NP_003986.2 ANF_receptor, 44 400 2.7e-75 * PKLNK, 534 786 3.2e-18 * Guanylate_cyc, 852 1038 5.6e-107 *
gi 4758292 ref NP_004436.1 Ephrin_lbd, 18 217 4.5e-110 * fn3, 355 455 1.8e-06 * fn3, 473 557 3.2e-18 * TM, o582 604i * PKLNK, 655 900 1.1e-22 * SAM, 930 997 6e-22 *
gi 4758606 ref NP_004508.1 Ank, 33 65 9.4e-09 * Ank, 66 98 1.6e-09 * Ank, 99 131 3.2e-07 * PKLNK, 193 449 1.3e-10 *
gi 477540 pir A49183 PKLNK, 16 250 7.9e-07 *
gi 5052670 gb AAD38665.1 AF145690_1 PKLNK, 122 375 4.7e-09 *
gi 57997202 emb CAD38856.2 Ank, 55 87 0.0025 * Ank, 88 120 0.0056 * PKLNK, 251 503 1.6e-06 *
gi 58530886 ref NP_001561.3 Death, 14 94 2.9e-16 * PKLNK, 210 496 2.6e-11 *
gi 6005792 ref NP_009130.1 Death, 26 106 4.4e-18 * PKLNK, 165 443 3e-12 *
gi 7020363 dbj BAA91097.1 PX, 17 122 1.3e-16 * PKLNK, 146 449 0.0028 *
gi 7243101 dbj BAA92598.1 PKLNK, 4 190 2e-63 *
gi 7291217 gb AAF46649.1 ANF_receptor, 107 481 1.4e-73 * PKLNK, 555 794 3.9e-10 * Guanylate_cyc, 860 1046 1.2e-99 *
gi 7294467 gb AAF49811.1 ANF_receptor, 64 423 3.9e-35 * PKLNK, 573 832 4.4e-16 * Guanylate_cyc, 898 1084 1.5e-89 *
gi 7301824 gb AAF56933.1 PKLNK, 28 268 2e-82 * HEAT, 383 419 0.0027 *
gi 24641273 PKLNK, 892 1151 1.4e-35 *