International Journal of Genomics / 2009 / Article / Tab 9

Research Article

Classification of Nonenzymatic Homologues of Protein Kinases

Table 9

List of PKLNKs which interact with a large number of proteins. The in vivo/in vitro protein-protein interaction data has been obtained from HPRD database [32].

PKLNKAccession code of the interacting proteinNameRole

NP_009130.1NP_001560Interleukin-1 receptor-associated kinase 1 isoform 1Partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B
NP_001561Interleukin-1 receptor-associated kinase 2Participate in the IL1-induced upregulation of NF-kappa B
NP_002459Myeloid differentiation primary response gene 88Functions as adapter protein in the association of IL-1 receptor associated kinase (IRAK) with the IL-1 receptor
NP_067681Toll-like receptor adaptor molecule 2Involved in Toll receptor siganling
NP_665802TNF receptor-associated factor 6Mediates signal transduction from members of the TNF receptor superfamily and from the members of the Toll/IL-1 family

NP_004436.1NP_001035090Myeloid/lymphoid or mixed-lineage leukemiaRegulates cell-cell adhesions downstream of Ras activation
NP_002077Growth factor receptor-bound protein 2 isoform 1Binds epidermal growth factor receptor. Involved in signal transduction pathway
NP_002961Spermidine/spermine N1-acetyltransferaseInvolved in the catabolic pathway of plymine metabolism
NP_004084Ephrin B2Mediates developmental events, especially in the nervous system and in erythropoiesis
NP_004432Ephrin receptor EphB1 precursorMediates developmental events, especially in the nervous system and in erythropoiesis
NP_005179Cas-Br-M (murine) ecotropic retroviral transforming sequenceAdaptor protein for receptor protein-tyrosine kinases, positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains
NP_005198v-crk sarcoma virus CT10 oncogene homologPlays a role in fibroblast transformation
NP_058431v-crk sarcoma virus CT10 oncogene homolog isoform aMember of an adapter protein family that binds to several tyrosine-phosphorylated proteins
NP_115500Haloacid dehalogenase-like hydrolase domain containing 2Hydrolase

NP_004508.1AAM77350LIMS2Is a focal adhesion protein that associates with integrin-linked kinases and involved in protein-protein interactions at adhesion sites between cells and the extracellular matrix
BAA18998Paxillin gammaA focal adhesion complex (FAC) which interacts with a wide array of molecules involved in managing the cells response to extracellular matrix components, growth factors, cell : cell interactions, and chemotatic signals.
NP_000202Integrin, beta 2 precursorCell-surface protein participates in cell adhesion as well as cell-surface mediated signaling
NP_000203Integrin beta chain, beta 3Participates in cell adhesion as well as cell-surface mediated signaling
NP_001003828Parvin, beta isoform aActin-binding proteins associated with focal contacts
NP_001744Caveolin 1Main component of the caveolae plasma membranes, links integrin subunits to the tyrosine kinase FYN which helps in cell cycle progression
NP_002084Glycogen synthase kinase 3 betaInvolved in energy metabolism, neuronal cell development, and body pattern formation
NP_002471Protein phosphatase 1, regulatory (inhibitor) subunit 12ARegulates interaction of actin and myosin downstream of the guanosine triphosphatase Rho
NP_0026043-phosphoinositide dependent protein kinase-1 isoform 1Phosphorylates and activates protein kinase B alpha and p70 S6 kinase
NP_004978LIM and senescent cell antigen-like domains 1Adaptor protein which may play role in integrin-mediated cell adhesion pr spreading
NP_005154v-akt murine thymoma viral oncogene homolog 1Mediator of growth factor-induced neuronal survival
NP_060692Parvin, alphaActin-binding protein associated with focal contacts
NP_066932Thymosin, beta 4Plays a role in regulation of actin polymerization, cell proliferation, migration, and differentiation
NP_071424Parvin, gammaActin-binding proteins associated with focal contacts
NP_110395Integrin-linked kinase-associated protein phosphatase 2CRegulates the kinase activity of integrin-linked kinase and participate in Wnt signaling
NP_391987Integrin beta 1 isoform 1C-1 precursorInvolved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response, and metastatic diffusion of tumor cells.

NP_000171.1NP_000400Guanylate cyclase activator 1A (retina)Activator of guanylate cyclase
NP_002089Guanylate cyclase activator 1B (retina)Activator of guanylate cyclase
NP_006263S100 calcium-binding protein, betaInvolved in cell cycle progression and differentiation
NP_009033Guanylate cyclase activator 2BActivator of guanylate cyclase receptor
O75916Regulator of G-protein signaling 9Inhibits signal transduction by increasing the GTPase activity of G-protein alpha subunits, involved in phosphotransduction

NP_003986.2NP_003986Natriuretic peptide receptor B precursorPrimary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity
NP_077720Natriuretic peptide precursor CPossesses potent natriuretic, diurectic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control

NP_061041.2NP_000446Serine/threonine protein kinase 11Regulates cell polarity and functions as a tumor suppressor
NP_001158Baculoviral IAP repeat-containing protein 4Inhibits apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2
NP_057373Calcium binding protein 39Calcium binding
NP_663304Mitogen-activated protein kinase kinase kinase 7 isoform BMediates signal transduction induced by TGF beta and morphogenetic protein and controls variety of cell functions including transcription regulation and apoptosis
NP_665802TNF receptor-associated factor 6Mediates signal transduction from members of the TNF receptor superfamily and from the members of the Toll/IL-1 family

NP_065731.3NP_004636CoilinThe protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the posttranscriptional modification of small nuclear and small nucleolar RNAs.
NP_036204CD93 antigen precursorInvolved in intercellular adhesion and in the clearance of apoptotic cells
NP_689494SCY1-like 1 binding protein 1Known to interact with SCY1-like family of kinase-like proteins

NP_001513.2NP_001513.2Guanylate cyclase 2FProbably plays a specific functional role in the rods and/or cones of photoreceptors.
NP_002089Guanylate cyclase activator 1B (retina)Activator of guanylate cyclase

NP_000897.2NP_006249Protein kinase, cGMP-dependent, type I isoform 2Protein phosphorylation
NP_002512Natriuretic peptide precursor B preproproteinFunctions as cardiac hormone, has role in natriuresis, diuresis, vasorlaxation inhibition of rennin, and aldosterone secretion, and has a key role in cardiovascular homeostasis
NP_000897Natriuretic peptide receptor 1Membrane bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides
NP_006163Natriuretic peptide precursor APotent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control
NP_060649Activating transcription factor 7 interacting proteinModulates transcription regulation and chromatin formation