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| PKLNK | Accession code of the interacting protein | Name | Role |
|
| NP_009130.1 | NP_001560 | Interleukin-1 receptor-associated kinase 1 isoform 1 | Partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B |
| NP_001561 | Interleukin-1 receptor-associated kinase 2 | Participate in the IL1-induced upregulation of NF-kappa B |
| NP_002459 | Myeloid differentiation primary response gene 88 | Functions as adapter protein in the association of IL-1 receptor associated kinase (IRAK) with the IL-1 receptor |
| NP_067681 | Toll-like receptor adaptor molecule 2 | Involved in Toll receptor siganling |
| NP_665802 | TNF receptor-associated factor 6 | Mediates signal transduction from members of the TNF receptor superfamily and from the members of the Toll/IL-1 family |
|
| NP_004436.1 | NP_001035090 | Myeloid/lymphoid or mixed-lineage leukemia | Regulates cell-cell adhesions downstream of Ras activation |
| NP_002077 | Growth factor receptor-bound protein 2 isoform 1 | Binds epidermal growth factor receptor. Involved in signal transduction pathway |
| NP_002961 | Spermidine/spermine N1-acetyltransferase | Involved in the catabolic pathway of plymine metabolism |
| NP_004084 | Ephrin B2 | Mediates developmental events, especially in the nervous system and in erythropoiesis |
| NP_004432 | Ephrin receptor EphB1 precursor | Mediates developmental events, especially in the nervous system and in erythropoiesis |
| NP_005179 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | Adaptor protein for receptor protein-tyrosine kinases, positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains |
| NP_005198 | v-crk sarcoma virus CT10 oncogene homolog | Plays a role in fibroblast transformation |
| NP_058431 | v-crk sarcoma virus CT10 oncogene homolog isoform a | Member of an adapter protein family that binds to several tyrosine-phosphorylated proteins |
| NP_115500 | Haloacid dehalogenase-like hydrolase domain containing 2 | Hydrolase |
|
| NP_004508.1 | AAM77350 | LIMS2 | Is a focal adhesion protein that associates with integrin-linked kinases and involved in protein-protein interactions at adhesion sites between cells and the extracellular matrix |
| BAA18998 | Paxillin gamma | A focal adhesion complex (FAC) which interacts with a wide array of molecules involved in managing the cells response to extracellular matrix components, growth factors, cell : cell interactions, and chemotatic signals. |
| NP_000202 | Integrin, beta 2 precursor | Cell-surface protein participates in cell adhesion as well as cell-surface mediated signaling |
| NP_000203 | Integrin beta chain, beta 3 | Participates in cell adhesion as well as cell-surface mediated signaling |
| NP_001003828 | Parvin, beta isoform a | Actin-binding proteins associated with focal contacts |
| NP_001744 | Caveolin 1 | Main component of the caveolae plasma membranes, links integrin subunits to the tyrosine kinase FYN which helps in cell cycle progression |
| NP_002084 | Glycogen synthase kinase 3 beta | Involved in energy metabolism, neuronal cell development, and body pattern formation |
| NP_002471 | Protein phosphatase 1, regulatory (inhibitor) subunit 12A | Regulates interaction of actin and myosin downstream of the guanosine triphosphatase Rho |
| NP_002604 | 3-phosphoinositide dependent protein kinase-1 isoform 1 | Phosphorylates and activates protein kinase B alpha and p70 S6 kinase |
| NP_004978 | LIM and senescent cell antigen-like domains 1 | Adaptor protein which may play role in integrin-mediated cell adhesion pr spreading |
| NP_005154 | v-akt murine thymoma viral oncogene homolog 1 | Mediator of growth factor-induced neuronal survival |
| NP_060692 | Parvin, alpha | Actin-binding protein associated with focal contacts |
| NP_066932 | Thymosin, beta 4 | Plays a role in regulation of actin polymerization, cell proliferation, migration, and differentiation |
| NP_071424 | Parvin, gamma | Actin-binding proteins associated with focal contacts |
| NP_110395 | Integrin-linked kinase-associated protein phosphatase 2C | Regulates the kinase activity of integrin-linked kinase and participate in Wnt signaling |
| NP_391987 | Integrin beta 1 isoform 1C-1 precursor | Involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response, and metastatic diffusion of tumor cells. |
|
| NP_000171.1 | NP_000400 | Guanylate cyclase activator 1A (retina) | Activator of guanylate cyclase |
| NP_002089 | Guanylate cyclase activator 1B (retina) | Activator of guanylate cyclase |
| NP_006263 | S100 calcium-binding protein, beta | Involved in cell cycle progression and differentiation |
| NP_009033 | Guanylate cyclase activator 2B | Activator of guanylate cyclase receptor |
| O75916 | Regulator of G-protein signaling 9 | Inhibits signal transduction by increasing the GTPase activity of G-protein alpha subunits, involved in phosphotransduction |
|
| NP_003986.2 | NP_003986 | Natriuretic peptide receptor B precursor | Primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity |
| NP_077720 | Natriuretic peptide precursor C | Possesses potent natriuretic, diurectic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control |
|
| NP_061041.2 | NP_000446 | Serine/threonine protein kinase 11 | Regulates cell polarity and functions as a tumor suppressor |
| NP_001158 | Baculoviral IAP repeat-containing protein 4 | Inhibits apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 |
| NP_057373 | Calcium binding protein 39 | Calcium binding |
| NP_663304 | Mitogen-activated protein kinase kinase kinase 7 isoform B | Mediates signal transduction induced by TGF beta and morphogenetic protein and controls variety of cell functions including transcription regulation and apoptosis |
| NP_665802 | TNF receptor-associated factor 6 | Mediates signal transduction from members of the TNF receptor superfamily and from the members of the Toll/IL-1 family |
|
| NP_065731.3 | NP_004636 | Coilin | The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the posttranscriptional modification of small nuclear and small nucleolar RNAs. |
| NP_036204 | CD93 antigen precursor | Involved in intercellular adhesion and in the clearance of apoptotic cells |
| NP_689494 | SCY1-like 1 binding protein 1 | Known to interact with SCY1-like family of kinase-like proteins |
|
| NP_001513.2 | NP_001513.2 | Guanylate cyclase 2F | Probably plays a specific functional role in the rods and/or cones of photoreceptors. |
| NP_002089 | Guanylate cyclase activator 1B (retina) | Activator of guanylate cyclase |
|
| NP_000897.2 | NP_006249 | Protein kinase, cGMP-dependent, type I isoform 2 | Protein phosphorylation |
| NP_002512 | Natriuretic peptide precursor B preproprotein | Functions as cardiac hormone, has role in natriuresis, diuresis, vasorlaxation inhibition of rennin, and aldosterone secretion, and has a key role in cardiovascular homeostasis |
| NP_000897 | Natriuretic peptide receptor 1 | Membrane bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides |
| NP_006163 | Natriuretic peptide precursor A | Potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control |
| NP_060649 | Activating transcription factor 7 interacting protein | Modulates transcription regulation and chromatin formation |
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