Table 2: Genes that were commonly altered in the liver, lung, and spleen of mice infected with WT. Y. pestis CO92 for 48 hours.

GenBank IDGene NameFunctionControl versus WT Y. pestis CO92 at 48 hours

AV309418N-myc downstream regulated 1 (Ndrg)Regulation of progression through cell cycle; inflammatory response; immune response23.117.514.6
BM234360Fibronectin 1 (Fn1)Acute-phase response5329.46.7
BC010337Keratin 7 (Krt7)Cytokine and chemokine mediated signaling pathway27.36.5
AY061760Nuclear factor, interleukin 3, regulated (Nfil3)Electron transport; fat cell differentiation7.53.76.1
AK013239Inhibitor of DNA binding 2 (Id2)Electron transport; cell motility; chemotaxis; inflammatory response; immune response; cell surface receptor linked signal transduction; cell-cell signaling; muscle development; circulation; positive regulation of cell proliferation30.5206
AK013765Endothelial cell growth factor 1 (platelet-derived) (Ecgf1)Immune response22.44.65.5
BG064671A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 (ADAMTS4)Regulation of cell growth; neutrophil apoptosis; inflammatory cell apoptosis; cell motility; immune response; response to virus; antigen processing and presentation; neutrophil chemotaxis; unfolded protein response; negative regulation of myelination; defense response to bacterium; positive regulation of chemokine biosynthesis4.24.35.4
AK004893Inter alpha-trypsin inhibitor, heavy chain 4 (Itih4)Chemotaxis; inflammatory response; immune response; signal transduction8.89.35.3
NM_031192Renin 1 structural (Ren1)Regulation of cell growth; regulation of protein amino acid phosphorylation; antiapoptosis; JAK-STAT cascade; negative regulation of insulin receptor signaling pathway1545.3
NM_008326Immunity-related GTPase family, M (Irgm)Immune response6.17.95.1
AW546137Bone morphogenic protein receptor, type II (serine/threonine kinase) (Bmpr2)Response to stress; stress-activated protein kinase signaling pathway2.82.25.6
AV328143ADP-ribosylation factor-like 4A (Arl4a)Unknown23.710.44.3
NM_011722Dynactin 6 (Dctn6)Immune response; cell surface receptor linked signal transduction3.75.24.2
BB667823Ring finger protein 125 (Rnf125)Immune response; response to virus11.17.24.1
BB561053Zinc finger, MYND domain containing 11 (Zmynd11)Acute-phase response3.611.94
AF004023Cd200 antigen (Cd200)Chemotaxis; inflammatory response; immune response; signal transduction2.73.33.8
BC025819Cytochrome P450, family 2, subfamily c, polypeptide 44 (Cyp2c44)Immune response; cell adhesion; antimicrobial humoral response2.52.33.8
AK006551Coenzyme Q10 homolog B (Coq10b)Apoptosis; immune response20.911.63.7
NM_011016Orosomucoid 2 (Orm2)Immune response7.42.93.5
AF022957Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (Anp32a)Somitogenesis; response to biotic stimulus; anterior/posterior pattern formation3.323.1
NM_023462Retinol binding protein 7, cellular (Rbp7)Immune response44.33
BB223018Schlafen 1 (Slfn1)Electron transport; lactation; regulation of epithelial cell differentiation3.53.52.8
BG076338F-box protein 21 (Fbxo21)Immune response11.14.22.7
NM_008458Serine (or cysteine) peptidase inhibitor, clade A, member 3C (Serpina3c)Regulation of progression through cell cycle; fever; apoptosis; inflammatory response; immune response; cell proliferation; regulation of cell proliferation; antimicrobial humoral response; neutrophil chemotaxis; positive regulation of chemokine biosynthesis; positive regulation of IL-6 biosynthesis; leukocyte migration7.27.12.5
AF047725Cytochrome P450, family 2, subfamily c, polypeptide 38 (Cyp2c38)Unknown2.52.62.5
BC018333Aldo-keto reductase family 1, member D1 (Akr1d1)NAD biosynthesis; pyridine nucleotide biosynthesis4.12.42.5
BC021340Poly (ADP-ribose) polymerase family, member 14 (Parp14)Immune response47.82.4
BB326709Doublecortin and CaM kinase-like 3 (Dcamkl3)Protein folding2.48.12.4
AF030178Phosphatidylinositol glycan anchor biosynthesis, class Q (Pigq)Cytokine and chemokine mediated signaling pathway3.85.42.3
NM_008262One cut domain, family member 1 (Onecut1)Phagocytosis; apoptosis; inflammatory response; immune response; cell surface receptor linked signal transduction30.94.32.3

Fold changes (FCs) shown were statistically significant (i.e., Benjamini and Hochberg corrected value and absolute consistency across all replicate experiments). A negative sign before values indicates downregulation.