Table 4: Selected gene expression alterations in the liver, lung, and spleen of mice infected with a lpp mutant of Y. pestis CO92, compared to WT Y. pestis.

GenBank IDGene NameWT versus MutC versus WTC versus Mut

Liver 12 hours

K01391B.subtilis tryptophan (trp) operon, complete cds.25.925.9
BB449248Apoptosis inhibitor 5 (Api5)3.02.8
L38424Bacillus subtilis dihydropicolinate reductase (jojE)−167.8−226.1

GenBank IDGene NameWT versus MutC versus WTC versus Mut

Spleen 12 hours

BB167641Cyclin D3 (Ccnd3)−4.23.8
BC027056Microtubule-associated protein, RP/EB family, member 2 (Mapre2)−2.62.0
BB636266Nemo like kinase (Nlk)−2.32.1
NM_013743Pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4)−2.73.1
AF402617BCL2-antagonist/killer 1 (Bak1)3.1−2.2
NM_009743Bcl2-like 1 (Bcl2l1)2.4−2.3
NM_010438Hexokinase 1 (Hk1)4.8−4.8
AY058908Anti-human CD37 antibody WR17 kappa light chain variable region4.0−2.41.6
L41881Immunoglobulin kappa chain variable 28 (V28) (Igk-V28)3.8−1.82.1
BG141874Transthyretin (Ttr)3.13.2

Liver 48 hours

AK014526Lipin 1 (Lpin1)−1.82.3
BE685667Cyclin D3 (Ccnd3)22.1
AF169388Procollagen, type IV, alpha 4 (Col4a4)23.0
BB305930Protocadherin 17 (Pcdh17)2.23.0
BM122301Transforming growth factor, beta receptor III (Tgfbr3)1.82.6
BC025105V-set and immunoglobulin domain containing 4 (Vsig4)−2.3−2.8
NM_015780Complement factor H-related 1 (Cfhr1)−2.9−3.4

Lung 48 hours

BC011338Baculoviral IAP repeat-containing 3 (Birc3)1.832.2
L16462B-cell leukemia/lymphoma 2 related protein A1a (Bcl2a1a)2.343.5
NM_007651CD53 antigen (Cd53)1.992.1
AF252873Chemokine (C-X-C motif) ligand 14 (Cxcl14)2.712.7
BC024886Coagulation factor III (F3)2.182.4
NM_007972Coagulation factor X (F10)2.413
BM238701Dual specificity phosphatase 16 (Dusp16)2.632.7
NM_007913Early growth response 1 (Egr1)3.033
AF065917Leukemia inhibitory factor (Lif)3.364.7
BB491008MARCKS-like 12.963.6
BB730139Prostaglandin E synthase (Ptges)2.553

Fold changes (FCs) shown were statistically significant (i.e., Benjamini and Hochberg corrected value and absolute consistency across all replicate experiments). A negative sign before values indicates downregulation. A dash “—" indicates that no statistical difference was observed. WT and mutant (Mut) refer to wild-type Y. pestis CO92 and its lpp mutant, respectively. C: control (uninfected) mice.