Gene Expression Profiling in Human High-Grade Astrocytomas
Table 3
The marker genes of three different grades of ACM.
Gene symbol
II-astro score
III-astro score
IV-astro score
Normal-score
II-mean (log base 2)
III-mean (log base 2)
IV-mean (log base 2)
Normal mean (log base 2)
EPHB1
15.4462
0
0
0
6.869894
2.55495
2.65409
2.72811
LOC732229
13.8658
0
0
0
5.460512
2.59371
2.77408
2.26366
C12orf39
8.5766
0
0
0
5.361751
2.238085
2.58682
2.48695
MARVELD3
7.8886
0
0
0
6.800398
2.37729
2.86839
2.39552
LOC283677
4.4758
0
0
0
3.883122
2.826663
2.71392
2.8898
C20orf42
3.5577
0
0
0
7.627308
2.859789
2.4558
2.52664
SPTLC3
3.2679
0
0
0
4.01698
2.255256
2.30132
2.59188
KCNQ1OT1
2.9128
0
0
0
4.103731
2.338234
2.2464
2.26363
FLJ21062
2.1167
0
0
0
4.753168
2.238085
2.48495
2.26875
ATP13A5
1.9707
0
0
0
3.214755
2.238085
2.2464
2.43345
PDXDC1
1.3847
0
0
0
3.134729
2.25661
2.26636
2.26363
CNNM2
0.8081
0
0
0
3.148803
2.27347
2.6133
2.54342
ZBTB39
0
15.0318
0
0
4.173501
6.19055
4.6856
4.68794
C6orf89
0
11.2219
0
0
2.621672
4.699428
2.91788
2.30613
LOC116236
0
11.0126
0
0
2.254329
4.397317
2.72612
2.44326
FKHL18
0
10.2107
0
0
2.258635
3.994112
2.2464
2.6121
CTRL
0
10.0666
0
0
2.526428
3.937424
2.31851
2.58541
TIRAP
0
9.5523
0
0
2.324936
4.216794
2.2464
2.75954
NEUROG1
0
2.5236
0
0
2.258056
3.768388
2.64751
2.27475
TMEM44
0
0.4603
0
0
2.315798
3.374982
2.45605
2.51802
RPUSD1
0
−0.647
0
0
4.034009
2.703442
3.84208
4.14466
DHRS7
0
−2.0711
0
0
3.425335
2.573317
3.60534
4.03533
AKAP7
0
−2.6126
0
0
4.723465
2.652648
5.11056
3.7332
PDE3B
0
−4.2169
0
0
5.989233
4.535432
6.10718
6.31594
C20orf160
0
0
14.9825
0
2.523126
2.790445
4.41487
2.27477
PKMYT1
0
0
11.89
0
2.644079
2.486864
3.84824
2.26751
TRPV2
0
0
10.5089
0
2.397686
2.732524
4.5048
3.31894
LEFTY2
0
0
5.3507
0
2.231583
2.258491
5.56688
2.28191
C20orf77
0
0
5.1848
0
2.333998
2.404051
3.48131
2.3379
MOBKL2C
0
0
3.8936
0
2.517987
2.58549
3.86723
2.45653
STAC
0
0
2.9965
0
2.275399
2.238151
6.32448
2.78522
GGA3
0
0
2.8351
0
2.295872
2.433914
3.46887
2.26651
VAV1
0
0
2.1584
0
2.396392
2.515654
4.53627
2.34353
TXNRD2
0
0
1.3886
0
2.582906
2.358745
3.38602
2.41848
SP100
0
0
0.9134
0
2.385938
2.339246
3.58699
2.37374
LCP2
0
0
0.7656
0
2.268675
2.292975
3.62601
2.88405
RHEB
0
0
0.6002
0
2.254732
2.244571
3.16583
2.31595
The first column lists the marker genes for different ACM WHO grades; the scores from 2th to 5th columns suggest the estimates of the class probabilities by PAM [4], which are similar to that used in linear discriminant analysis (LDA); the means from 6th to 9th columns represent the average values of log (base 2) gene expression. Bold indicates a marker gene of one WHO grade ACM relative to other WHO grades which are overexpressional; italic indicates those that are underexpressional.
