Applications of Different Weighting Schemes to Improve Pathway-Based Analysis

Table 3

Top 20 canine pathways selected in the global test under each weighting scheme (PID stands for pathway identification number).

	Weighting schemes
	Uniform		absT		Qdiff		RWV		RWM
Ranks	PID	𝑃-value	PID	𝑃-value	PID	𝑃-value	PID	𝑃-value	PID	𝑃-value
1	117	.00003	151	.00000	368	.00003	17	.00000	39	.00000
2	39	.00004	391	.00000	39	.00004	391	.00000	40	.00000
3	394	.00004	326	.00001	217	.00006	368	.00001	223	.00001
4	217	.00007	360	.00001	394	.00007	117	.00001	160	.00001
5	304	.00007	73	.00001	73	.00007	151	.00001	295	.00001
6	183	.00008	117	.00002	304	.00007	202	.00001	304	.00001
7	40	.00009	39	.00002	247	.00007	39	.00001	283	.00001
8	440	.00009	156	.00002	40	.00008	175	.00001	217	.00001
9	159	.00011	133	.00002	440	.00008	210	.00002	387	.00001
10	17	.00015	217	.00002	117	.00010	247	.00002	64	.00001
11	151	.00017	94	.00002	183	.00010	394	.00002	421	.00001
12	45	.00017	375	.00002	157	.00010	239	.00002	135	.00002
13	391	.00017	40	.00002	64	.00011	45	.00002	129	.00002
14	368	.00018	261	.00002	159	.00015	100	.00002	374	.00002
15	192	.00018	192	.00002	45	.00018	310	.00002	165	.00002
16	261	.00019	154	.00002	261	.00020	326	.00002	183	.00002
17	87	.00025	157	.00003	151	.00020	304	.00003	265	.00002
18	422	.00028	420	.00003	391	.00020	281	.00003	20	.00002
19	223	.00032	320	.00003	17	.00020	360	.00003	397	.00002
20	354	.00039	422	.00003	192	.00025	336	.00003	17	.00002
Total 𝑃-values		.00307		.00037		.00236		.00034		.00027
Average 𝑃-value		.00015		.00002		.00012		.00002		.00001