Applications of Different Weighting Schemes to Improve Pathway-Based Analysis

Table 6

Seven new significant canine pathways selected in the global test under absT scheme: 𝑃 values and ranks of them are compared to those under uniform weight.

Pathway name	𝑃-values		Ranks
	Uniform	absT	Uniform	absT
(PID = 133) Activation of Csk by cAMP-dependent protein kinase inhibits signaling through the T cell receptor	.1006	.00002	258	6
(PID = 156) Steps in the glycosylation of mammalian N-linked oligosaccarides	.1308	.00002	278	6
(PID = 375) PTEN-dependent cell cycle arrest and apoptosis	.4451	.00002	371	6
(PID = 154) TPO signaling pathway	.5504	.00002	389	6
(PID = 420) Trefoil factors initiate mucosal healing	.2226	.00003	330	17
(PID = 320) CDK regulation of DNA replication	.5563	.00003	390	17