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Comparative and Functional Genomics
Volume 2011 (2011), Article ID 878973, 13 pages
http://dx.doi.org/10.1155/2011/878973
Research Article

Cross-Genome Comparisons of Newly Identified Domains in Mycoplasma gallisepticum and Domain Architectures with Other Mycoplasma species

1Equipe de Bioinformatique, Laboratoire de Biochimie et Génétique Moléculaire, Université de La Réunion, 15 avenue René Cassin, La Réunion, 97715 Saint Denis Messag Cedex 09, France
2National Centre for Biological Sciences, GKVK Campus, Bellary Road, Bangalore 560065, India

Received 30 July 2010; Revised 21 February 2011; Accepted 23 May 2011

Academic Editor: G. Pesole

Copyright © 2011 Chandra Sekhar Reddy Chilamakuri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Accurate functional annotation of protein sequences is hampered by important factors such as the failure of sequence search methods to identify relationships and the inherent diversity in function of proteins related at low sequence similarities. Earlier, we had employed intermediate sequence search approach to establish new domain relationships in the unassigned regions of gene products at the whole genome level by taking Mycoplasma gallisepticum as a specific example and established new domain relationships. In this paper, we report a detailed comparison of the conservation status of the domain and domain architectures of the gene products that bear our newly predicted domains amongst 14 other Mycoplasma genomes and reported the probable implications for the organisms. Some of the domain associations, observed in Mycoplasma that afflict humans and other non-human primates, are involved in regulation of solute transport and DNA binding suggesting specific modes of host-pathogen interactions.