The Influence of 3′UTRs on MicroRNA Function Inferred from Human SNP Data
Distribution of SNP density, DAF, and MAF surrounding miRNA target sites. The SNP density (a), the fraction of SNPs for minor alleles (b) and derived alleles (c) obtained from all miRNA target genes having SNPs for the 200 nucleotides on both sides of the 5′ end of miRNA target sites are shown. The average SNP density and fraction of minor and derived alleles from non-miRNA target genes are depicted in solid lines. Dotted lines indicate the 5′ end of miRNA target sites (middle), upstream bound (left), and downstream bound (right). Also shown are the P values for the occurrence of the window sizes from simulation tests.