High Levels of Sequence Diversity in the 5′ UTRs of Human-Specific L1 Elements

Table 2

Age estimation of human-specific L1 elements based on each L1 component.

Subfamily^a	Subfamily^b	No. of full-length L1 elements	5′ UTR Age ± SD (myrs)	ORF1 Age ± SD (myrs)	ORF2 Age ± SD (myrs)	3′ UTR only Age ± SD (mys)	pORF2 and 3′ UTR Age ± SD (myrs)^b
L1PA3	L1PA3-1A; L1PA3-1Aa; L1PA3-1B; L1PA3-1Ba; L1PA3-1Bb; L1PA2-1A	106	20.30±0.65	12.83±0.71	11.31±0.73	15.32±2.11	12.71±0.63
L1PA2	L1PA2-1B; L1PA2-1C; L1PA2-1D; L1PA2-1Da; L1PA2-1Db; L1PA2-1E	147	13.85±0.38	9.15±0.59	9.63±0.69	11.32±1.14	7.62±0.47
L1HS-1AB	L1HS-1A; L1HS-1B	32	8.74±0.53	5.50±0.57	4.88±0.63	10.48±1.87	5.09±0.56
L1HS-preTa	L1HS-preTa	62	7.22±0.41	3.95±0.41	3.79±0.89	4.15±0.84	3.13±0.25
L1HS-Ta0	L1HS-Ta0	38	4.90±0.33	3.25±0.42	3.29±0.47	2.96±0.51	2.73±0.22
L1HS-Ta1	L1HS-Ta1	58	4.38±0.65	2.35±0.43	2.28±0.44	2.29±0.41	1.94±0.20
Average		443^c	9.90±0.49	6.17±0.52	5.86±0.64	7.75±1.15	5.54±0.39

^aIn this study.
^bSource Lee et al. [23].
^cTotal number of L1 elements.