Overview of posttranscriptional gene regulation by Sam68, eIF4E, La, and HuR in tumorigenesis. In cancer cells, RBPs are posttranslationally modified by aberrantly active signaling pathways that activate their binding to targets encoding proteins implicated in tumorigenesis. The steps of mRNA metabolism regulated by RBPs are indicated. (+) and (–) specify up- or downregulation. P and CH3–CO indicate phosphorylation and acetylation of RBPs. EMT: epithelial to mesenchymal transition.
