Table 2: Kinase sub-families with abnormal distribution in fugu. Overall function of each of the family is also indicated.


Highly represented families
JakAReceptor tyrosine kinase. Activates STAT involved in interferon signaling [7]
LmrReceptor tyrosine kinase involved in apoptosis [8]
PDGFRReceptor tyrosine kinase activating factors for growth, differentiation, development [7]
EphReceptor tyrosine kinase component of developmental pathways [9]
InsRReceptor that binds insulin and has a tyrosine-protein kinase activity [10]
PIMPhosphorylating chromatin proteins and controlling transcription [11]
CDKLMediates phosphorylation of MECP2 [12]
TrioGuanine nucleotide exchange factors that mediate cell invasiveness [13]
DYRKDirects cellular response to stress conditions and also implicated in neuropathological characteristics of Down’s syndrome [14, 15]
TrkReceptor for neurotrophin-3 (NT-3) [16]
SrcNonreceptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation [17]
VEGFRThe VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability [18]
Sgk496Induces both caspase-dependent apoptosis and caspase-independent cell death [19]
TrblInteracts with MAPK kinases and regulates activation of MAP kinases [20]
WnkControls sodium and chloride ion transport [21]

Underrepresented families
KISFunction unknown
MLCKCalcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains [22]
MLKInvolved in the JNK pathway [23]
MAPKAPKIntegrative element of signaling in both mitogen and stress responses [24]
CDKInvolved in regulation of cell cycle by binding to cyclins [25]
CAMKKCalcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes [26]
Ste7MAP2K homologous to yeast Ste7 [27]