Epigenetic Regulation of B Lymphocyte Differentiation, Transdifferentiation, and Reprogramming

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="564381.fig.002a" src="https://static.hindawi.com/articles/ijg/volume-2012/564381/figures/564381.fig.002a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>Transdifferentiation</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="564381.fig.002b" src="https://static.hindawi.com/articles/ijg/volume-2012/564381/figures/564381.fig.002b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Reprograming to pluripotency</td></tr></table></td></tr></table>

<table>Transdifferentiation and reprogramming of B cells. (a) Ectopic expression of C/EBP in pre-B cells induces their transdifferentiation into macrophages. Epigenetic changes during the process are shown. (b) B cells can be reprogrammed to pluripotency by fusion with ESCs (heterokaryon) or by transgenic induction of Oct4, Sox2, Klf4 and c-Myc (iPS).</table>

International Journal of Genomics

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Figure 2: Epigenetic Regulation of B Lymphocyte Differentiation, Transdifferentiation, and Reprogramming 