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Comparative and Functional Genomics
Volume 2012, Article ID 678761, 5 pages
http://dx.doi.org/10.1155/2012/678761
Research Article

TnpPred: A Web Service for the Robust Prediction of Prokaryotic Transposases

1Center for Bioinformatics and Genome Biology, Fundación Ciencia para la Vida Y Facultad de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile
2Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile

Received 1 June 2012; Revised 20 August 2012; Accepted 18 September 2012

Academic Editor: G. Pesole

Copyright © 2012 Gonzalo Riadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Transposases (Tnps) are enzymes that participate in the movement of insertion sequences (ISs) within and between genomes. Genes that encode Tnps are amongst the most abundant and widely distributed genes in nature. However, they are difficult to predict bioinformatically and given the increasing availability of prokaryotic genomes and metagenomes, it is incumbent to develop rapid, high quality automatic annotation of ISs. This need prompted us to develop a web service, termed TnpPred for Tnp discovery. It provides better sensitivity and specificity for Tnp predictions than given by currently available programs as determined by ROC analysis. TnpPred should be useful for improving genome annotation. The TnpPred web service is freely available for noncommercial use.