Research Article

Functional Genomic Analysis of Variation on Beef Tenderness Induced by Acute Stress in Angus Cattle

Table 2

Top significant pathways and functions.

IDMolecules in networkScoreFocus moleculesTop functions

1Akt, Ap1, ARG2, ASGR1, ATF3, CCL8, CCL24, CLDN11, CNN1, CREM, CXCL1, DLL4, ERK1/2, FABP4, FASN, G0S2, hCG, Histone h3, HSPA1A/HSPA1B, IL13, IL12A, MAPKAP1, NFkB (complex), NPR3, Nr1h, NR4A3, PCK1, PDGF, PPP1R15A, RCAN1, RET, RGS2, SCD, SDC4, TNFRSF12A5727Cellular growth and proliferation, cellular movement, lipid metabolism

2Aconitase, ANKRD1, AP2B1, APCS, ASPM, BLNK, CA12, CDX2, DGAT2, EFNA3, ENPP1, FCGR3A, GADD45G, HAS1, HDGF, HNF1A, HTT, IFRD1, IgG, IL1B, ITPA, KIF20A, NGEF, PFK, PPL, RARA, RNA polymerase II, S100G, SERPING1, SGK2, SIM1, SOAT2, TGFB1, UGT1A8, YY12113Embryonic development, reproductive system development and function, nutritional disease

3ABLIM, ACP2, ACSL5, ADCY9, ARPC1A, ATPIF1, CIDEC, CREBBP, DUSP3, DYRK3, FBP2, FSH, GLUL, GNLY, HGD, HOXB6, ING2, LEP, Lh, LHCGR, LOC81691, NR2F1, NR3C1, NR5A1, P4HA2, PDLIM3, PLCL1, POP5, PRKX, RAB5C, RGS5, RGS16, SREBF1, THRSP, TLK1118Drug metabolism, endocrine system development and function, lipid metabolism

4NAALAD2, RORA21Amino acid metabolism, small molecule biochemistry, gene expression

5FIGLA, TEKT121Cell cycle, reproductive system development and function, cell death

6ZHX1, ZHX321Gene expression

7AGTR1, HSPA6, RFWD221Cardiovascular system development and function, organ morphology, organismal injury and abnormalities

8AHR, GPI, STEAP421Cell cycle, cell morphology, cell-to-cell signaling and interaction

9CBX4, HOXA2, MBD1, MEOX121Gene expression, embryonic development, organismal development

10FBL, NFE2, PSMD14, STMN1, TUBB121Cell morphology, hematological system development and function, inflammatory response

11DMD, SGCA, SGCB, SGCD, SGCE, SGCG11Developmental disorder, genetic disorder, skeletal and muscular disorders