Figure 2: Characteristics of the Myog locus in differentiating muscle. (a) Conservation across mammalian species is plotted across the Myog locus representing the region from −7.0 kb to +2.5 kb for the transcription start site. The map shows the well-characterized proximal promoter (P) and three predicted enhancers (E1, E2, and E3) that remain uncharacterized. (b) Summary of myogenin locus characteristics as identified from high-throughput studies of muscle cells. Regions enriched for total Histone H3 acetylation or for acetylation at histone H3 lysine 27 (H3K27ac) are shown in orange. DNase I hypersensitive sites are shown in black. Regions marked by methylation of histone H3 lysine 4 (H3K4me1, H3K4me2, and H3K4me3) are shown in green. The positioning of MyoD and Myog binding sites as identified by ChIP-Seq studies are shown.