The α₁AT and TIMP-1 Gene Polymorphism in the Development of Asthma

Table 4

Distribution of allele frequencies of SNPs of α ₁AT and TIMP-1 genes in asthma patients and control group.

SNP	Patients	Control	𝜒^2	* P value	OR (95% CI)^†
Allele
Val213Ala (𝛼1AT)
T	350 (86.63%)	368 (90.19%)
C	54 (13.36%)	40 (9.80%)	0.44	0.51	1.15 (0.78–1.70)
Glu363Lys (𝛼1AT)
G	321 (79.45%)	368 (90.19%)
A	83 (20.54%)	40 (9.80%)	17.78	0.001	2.98 (1.79–4.96)
Glu376Asp (𝛼1AT)
A	308 (76.23%)	331 (81.12%)
C	96 (23.76%)	77 (18.87%)	0.74	0.39	1.15 (0.85–1.57)
rs5953060 (TIMP-1)
C	157 (50.48%)	154 (54.61%)
G	154 (49.52%)	128 (45.39%)	0.50	0.48	1.11 (0.84–1.46)
3774 (TIMP-1)
G	265 (85.21%)	271 (96.09%)
A	46 (14.79%)	11 (3.91%)	7.04	0.008	1.68 (0.27–2.22)
rs4898 Phe124Phe (TIMP-1)
T	165 (53.05%)	192 (68.08%)
C	146 (46.95%)	90 (31.21%)	5.38	0.02	1.39 (1.06–1.82)
rs6609533 (TIMP-1)
G	188 (60.45%)	189 (67.02%)
A	123 (39.55%)	93 (32.98%)	1.06	0.30	1.16 (0.88–1.53)
rs11551797 Ile158Ile (TIMP-1)
C	307 (98.71%)	272 (96.45%)
T	4 (1.29%)	10 (3.55%)	1.85	0.17	0.39 (0.07–2.28)
rs2070584 (TIMP-1)
G	160 (51.45%)	171 (60.64%)
T	151 (48.55%)	111 (39.36%)	2.03	0.15	1.22 (0.93–1.61)
rs2070534 (TIMP-1)
A	165 (53.05%)	169 (59.93%)
G	146 (46.95%)	113 (40.07%)	0.99	0.32	1.15 (0.87–1.52)

* P values were obtained after adjusting it with age, BMI, and SI by regression analysis using SPSS 12 software. ^†OR (95% CI): odds ratio (95% confidence interval).