RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response

Figure 2

Structure of p53 and dominant-negative behavior of mutant p53 toward wild-type p53. p53 is composed of three functional domains including NH₂-terminal transactivation domain (TA) followed by central sequence-specific DNA-binding domain (DB) and COOH-terminal oligomerization domain (OD) (upper panel). Lower panel shows the dominant-negative behavior of mutant p53 against wild-type p53.