RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response
Figure 5
Distinct regulatory role of RUNX family on p53 in response to DNA damage. Under our experimental conditions, RUNX1 as well as RUNX3 acts as a positive regulator for p53 in response to DNA damage, whereas DNA damage-induced proapoptotic activity of p53 is strongly abrogated by RUNX2.
