A Bayesian Hierarchical Model for Relating Multiple SNPs within Multiple Genes to Disease Risk

Figure 1

Directed acyclic graph describing the structure of the model. Boxes describe observed data; circles represent latent variables or model parameters. Single arrows denote stochastic relationships, while double arrows denote deterministic relationships. The first rectangle illustrates the relations of disease status and genes at the subject (i) level; the second rectangle illustrated the relations of external information and first level coefficient 𝛽_𝑔 at the gene (𝑔) level; the third rectangle illustrates the relations of weighted SNP effects and gene burden index at SNP (s) level.