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International Journal of Genomics
Volume 2013, Article ID 410407, 7 pages
http://dx.doi.org/10.1155/2013/410407
Research Article

Association of Genetic Variation in Calmodulin and Left Ventricular Mass in Full-Term Newborns

1Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Ulical Powstańców Wielkopolskich 72, 71-111 Szczecin, Poland
2Department of Cardiology, Pomeranian Medical University, Szczecin, Poland
3Department of Pediatrics, Pomeranian Medical University, Szczecin, Poland

Received 17 July 2013; Accepted 20 September 2013

Academic Editor: Giulia Piaggio

Copyright © 2013 Iwona Gorący et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Calmodulin II (CALM2) gene polymorphism might be responsible for the variation in the left ventricular mass amongst healthy individuals. The aim was to evaluate the correlation between left ventricular mass (LVM) and g.474955027G>A (rs7565161) polymorphism adjacent to the CALM2 gene. Healthy Polish newborns (n = 206) were recruited. Two-dimensional M-mode echocardiography was used to assess LVM. Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing analyses. The carriers of the G allele of the CALM2 polymorphism had significantly higher left ventricular mass/weight (LVM/BW) values, when compared with newborns homozygous for the A allele (3.1 g/m2 versus 2.5 g/m2, = 0.036). The AG genotype of CALM2 was associated with the highest values of LVM/BW, exhibiting a pattern of overdominance (2.9 g/kg versus 3.1 g/kg versus 2.5 g/kg, = 0.037). The results of this study suggest that G>A CALM2 polymorphism may account for subtle variation in LVM at birth.