|
| Reference | Subsite | Population | Study size | Gene SNP | Odds ratio (P value) |
|
| Sliwinski et al. [240] | Laryngeal | Polish | 641 (288 cases, 353 controls) | Rad51 G135C
XRCC3 C722T | 2.92 (<0.0001)
4.03 (<0.0001) |
|
| Romanowicz-Makowska et al. [241] | Laryngeal
| Polish | 506 (253 cases, 253 controls) | Rad51 G135C
XRCC2 G31479A
XRCC2 C41657T | NS [3.43 (0.073)]
NS [3.81 (0.061)]
NS [2.14 (0.061)] |
|
| Werbrouck et al. [242] | All | Belgium | 169 cases, 352 controls | XRCC3 C722T
Rad51 G-3429C
Lig4 C26T
Ku70 C1310G
Ku80 c.2110-2408
G>A | 1.96 (0.02)
0.43 (0.05)
0.43 (0.01)
NS
NS |
|
| Cui et al. [243] | | North American | 443 cases (including oesophageal), 912 controls | XPG c.1104 | 0.47 (<0.05) |
|
| dos Reis et al. [244] | Oral cavity | Brazil | 300 (150 cases, 150 controls) | XRCC1 Arg194Trp, Arg399Gln
XRCC3 Thr241Met | NS
NS |
|
| Pawlowska et al. [245] | Laryngeal | Polish | 506 (256 cases, 256 controls) | hOGG1 Ser326Cys | 2.96 (0.012) |
|
|
Kietthubthew et al. [246] | Oral cavity | Thai (betel quid endemic) | 106 cases, 164 controls | XRCC1 Arg194Trp, exon 6 | NS |
| XRCC3 Thr241Met | 3.3 (0.01) |
|
| | | | | XRCC3 rs3212057 | 6.0 (<0.01) |
| Gresner et al. [247] | All | Polish | 81 cases, 111 controls | Rad51
rs5030789 AA | 0.33 (<0.05) |
| | | | | Rad51
rs1801321 TT | 0.1 (<0.05) |
|
| Zhang et al. [248] | All | North American | 706 cases, 1196 controls | hOGG1 Ser326Cys | NS |
|
| Elahi et al. [249] | All | North American | 169 cases, 338 controls | hOGG1 Ser326Cys
Cys326Cys | 1.6 (<0.05)
4.1 (<0.05) |
|
| Majumder et al. [225] | All | Indian | 180 cases, 150 controls | XRCC1 c.194, c.399 | NS |
|
| Mahjabeen et al. [120] | Not specified | Pakistani | 300 cases, 300 controls | APEX1
13T<GG
Ser129Arg
Val131Gly | 4.97* (0.0001)
11.74* (0.0001)
5.12* (0.0001) |
|
| Ramachandran et al. [250] | Oral cavity | Indian | 110 cases, 110 controls | XRCC1 c.194
c.280
c.399
XPD c.751 | 3.09 (<0.0001)
NS
2.37 (<0.0001)
2.10 (0.003) |
|
| Tae et al. [251] | All | Korean | 147 cases, 168 controls | XRCC1 R194W
R280H, R399G | 2.61 (<0.05)
NS |
|
| Kumar et al. [118] | Not specified | North Indian | 75 cases, 75 controls | XRCC1 Arg399Gln
XPD Lys 751Gln
hOGG1 Ser326Cys | NS |
|
| Kumar et al. [228] | Not specified | North Indian | 278 cases, 278 controls | XRCC1 Arg194Trp
Arg280His
Arg399Gln
XPD Lys751Gln | 0.72 (0.03)
NS
0.64 (0.003)
1.75 (0.002) |
|
| Kowalski et al. [252] | All | Polish | 92 cases, 124 controls | XRCC1 Arg194Trp
Arg399Gln | NS |
|
|
Yen et al. [253] |
Oral cavity |
Taiwan |
103 cases, 98 controls | XRCC1 Arg194Trp
XRCC2 (5′ locus)
XRCC3 Thr241Met
XRCC4 T139G | NS |
| “pseudo-haplotype” multiple concurrent SNPs | 2–2.45 (0.03)
3–5.03 (0.013)
4–10.1 (0.036) |
|
| Tseng et al. [254] | Oral cavity | Taiwan | 318 cases, 318 controls(1) | XRCC4 c247
G1394T
rs28360317
rs1805377 | 2.04 (<0.05)
NS
NS
NS |
|
| Chiu et al. [255] | Oral cavity | Taiwan | 318 cases, 318 controls(1) | XRCC4 G1394T
rs28360071
rs28360217
rs1805377 | NS
1.55 (<0.05)
NS
NS |
|
| Chiu et al. [256] | Oral cavity | Taiwan | 292 cases, 290 controls | ERCC6
c.399 (A/A)
c.399 (G/G, G/A)
c.399 (Any A)
c.1097
c.1413 | 1.82 (<0.05)
NS
1.43 (<0.05)
NS
NS |
|
| Hsu et al. [257] | Oral cavity | Taiwan | 600 cases, 600 controls(1) | Ku80 G-1401T
C-319T
Intron19 |
1.603 (<0.05)(2)
NS
NS |
|
| Bau et al. [258] | Oral cavity | Taiwan | 318 cases, 318 controls(1) | Ku70 T991C
G-57C
A-31G
Intron 3 | 2.15 (<0.05)
NS
NS
NS |
|
| Bau et al. [99] | Oral cavity | Taiwan | 620 cases, 620 controls | ATM
rs189037
rs600931
rs652311
rs228589
rs227092
rs227060 | 1.61 (<0.05)
NS
NS
NS
NS
NS |
|
|
Flores-Obando et al. [259] | Meta-analysis | Multiple | | XPA A23G
XPD C22541A/A
XPD A35931C
XPD Asp312Asn
XPD C23047G
XPD C23051G
XPC PAT
XPC Lys939Gln
XPC Ala499Val
XPF T2063A
ERCC1 C8092A
XRCC1 exon 6 T/T
XRCC1 exon 10
XRCC1 exon 9
XRCC3 Thr241Met | NS
0.74 (<0.05)
NS
1.14 (0.05)
NS
NS
NS
NS
1.56 (<0.05)
NS
NS
1.69 (<0.05)
NS
NS
NS |
|
| Zhai et al. [122] | All | North America | 872 cases, 1044 controls | NEIL1 g.46434077
NEIL1 g.46438282
NEIL2 g.4102971CC | NS
NS
1.30 (<0.05) |
|
