Table 1

ReferenceSubsitePopulationStudy sizeGene SNPOdds ratio (P value)

Sliwinski et al. [240]LaryngealPolish641 (288 cases, 353 controls)Rad51 G135C
XRCC3 C722T
2.92 (<0.0001)
4.03 (<0.0001)

Romanowicz-Makowska et al. [241]Laryngeal
Polish506 (253 cases, 253 controls)Rad51 G135C
XRCC2 G31479A
XRCC2 C41657T
NS [3.43 (0.073)]
NS [3.81 (0.061)]
NS [2.14 (0.061)]

Werbrouck et al. [242]AllBelgium169 cases, 352 controlsXRCC3 C722T
Rad51 G-3429C
Lig4 C26T
Ku70 C1310G
Ku80 c.2110-2408
G>A
1.96 (0.02)
0.43 (0.05)
0.43 (0.01)
NS
NS

Cui et al. [243]North American443 cases (including oesophageal), 912 controlsXPG c.11040.47 (<0.05)

dos Reis et al. [244]Oral cavityBrazil300 (150 cases, 150 controls)XRCC1 Arg194Trp, Arg399Gln
XRCC3 Thr241Met
NS
NS

Pawlowska et al. [245]LaryngealPolish506 (256 cases, 256 controls)hOGG1 Ser326Cys2.96 (0.012)

Kietthubthew et al. [246]Oral cavityThai (betel quid endemic)106 cases, 164 controlsXRCC1 Arg194Trp, exon 6NS
XRCC3 Thr241Met3.3 (0.01)

XRCC3 rs32120576.0 (<0.01)
Gresner et al. [247]AllPolish81 cases, 111 controlsRad51
rs5030789 AA
0.33 (<0.05)
Rad51
rs1801321 TT
0.1 (<0.05)

Zhang et al. [248]AllNorth American706 cases, 1196 controlshOGG1 Ser326CysNS

Elahi et al. [249]AllNorth American169 cases, 338 controlshOGG1 Ser326Cys
Cys326Cys
1.6 (<0.05)
4.1 (<0.05)

Majumder et al. [225]AllIndian180 cases, 150 controlsXRCC1 c.194, c.399NS

Mahjabeen et al. [120]Not specifiedPakistani300 cases, 300 controlsAPEX1
13T<GG
Ser129Arg
Val131Gly
4.97* (0.0001)
11.74* (0.0001)
5.12* (0.0001)

Ramachandran et al. [250]Oral cavityIndian110 cases, 110 controlsXRCC1 c.194
c.280
c.399
XPD c.751
3.09 (<0.0001)
NS
2.37 (<0.0001)
2.10 (0.003)

Tae et al. [251]AllKorean147 cases, 168 controlsXRCC1 R194W
R280H, R399G
2.61 (<0.05)
NS

Kumar et al. [118]Not specifiedNorth Indian75 cases, 75 controlsXRCC1 Arg399Gln
XPD Lys 751Gln
hOGG1 Ser326Cys
NS

Kumar et al. [228]Not specifiedNorth Indian278 cases, 278 controlsXRCC1 Arg194Trp
Arg280His
Arg399Gln
XPD Lys751Gln
0.72 (0.03)
NS
0.64 (0.003)
1.75 (0.002)

Kowalski et al. [252]AllPolish92 cases, 124 controlsXRCC1 Arg194Trp
Arg399Gln
NS

Yen et al. [253] Oral cavity Taiwan 103 cases, 98 controlsXRCC1 Arg194Trp
XRCC2 (5′ locus)
XRCC3 Thr241Met
XRCC4 T139G
NS
“pseudo-haplotype” multiple concurrent SNPs2–2.45 (0.03)
3–5.03 (0.013)
4–10.1 (0.036)

Tseng et al. [254]Oral cavityTaiwan318 cases, 318 controls(1)XRCC4 c247
G1394T
rs28360317
rs1805377
2.04 (<0.05)
NS
NS
NS

Chiu et al. [255]Oral cavityTaiwan318 cases, 318 controls(1)XRCC4 G1394T
rs28360071
rs28360217
rs1805377
NS
1.55 (<0.05)
NS
NS

Chiu et al. [256]Oral cavityTaiwan292 cases, 290 controlsERCC6
c.399 (A/A)
c.399 (G/G, G/A)
c.399 (Any A)
c.1097
c.1413
1.82 (<0.05)
NS
1.43 (<0.05)
NS
NS

Hsu et al. [257]Oral cavityTaiwan600 cases, 600 controls(1)Ku80 G-1401T
C-319T
Intron19
1.603 (<0.05)(2)
NS
NS

Bau et al. [258]Oral cavityTaiwan318 cases, 318 controls(1)Ku70 T991C
G-57C
A-31G
Intron 3
2.15 (<0.05)
NS
NS
NS

Bau et al. [99]Oral cavityTaiwan620 cases, 620 controlsATM
rs189037
rs600931
rs652311
rs228589
rs227092
rs227060
1.61 (<0.05)
NS
NS
NS
NS
NS

Flores-Obando et al. [259]Meta-analysisMultipleXPA A23G
XPD C22541A/A
XPD A35931C
XPD Asp312Asn
XPD C23047G
XPD C23051G
XPC PAT
XPC Lys939Gln
XPC Ala499Val
XPF T2063A
ERCC1 C8092A
XRCC1 exon 6 T/T
XRCC1 exon 10
XRCC1 exon 9
XRCC3 Thr241Met
NS
0.74 (<0.05)
NS
1.14 (0.05)
NS
NS
NS
NS
1.56 (<0.05)
NS
NS
1.69 (<0.05)
NS
NS
NS

Zhai et al. [122]AllNorth America872 cases, 1044 controlsNEIL1 g.46434077
NEIL1 g.46438282
NEIL2 g.4102971CC
NS
NS
1.30 (<0.05)

Crude odds ratio.
Same group/cohort.
Only in Areca-nut exposed subgroup.