GOLink: Finding Cooccurring Terms across Gene Ontology Namespaces
Figure 3
Statistical assessment of GOLink’s ability to predict whether or not a gene has a role in a particular Biological Process based on its Molecular Function terms. GO annotation terms from genes in a positive and a negative list were matched against terms in the three GOLink terms lists. (a) The measures of sensitivity, specificity, accuracy, positive predictive value, and negative predictive value as well as the proportion of genes reported in the positive and negative lists. (b) The same measures but showing the impact following the removal of 11 known true positives from the negative list and the removal from the GOLink terms lists of the term “protein binding,” which has relevance across both the positive and negative gene lists.
