DUSP1 Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression

Table 1

Subjects’ characteristics.

	All^a	MetS+^b	MetS−^b
Number of subjects (% male)	1906 (31.3%)	1549 (33.8%)	350 (20.9%)
Age (years)	43.1±10.6	44.0±10.6	38.9 ± 9.7
BMI (kg/m^2)	51.6±8.8	51.8±8.9	50.9 ± 8.6
Waist girth (cm)	140.4±17.6	141.5±17.2 (100%)	135.4±18.5 (100%)
Fasting glucose (mmol/L)	6.55±2.35	6.87±2.45 (74.2%)	5.13±0.95 (10.9%)
Lipid profile
Total-C (mmol/L)	4.68±0.96	4.65±0.99	4.79±0.82
LDL-C (mmol/L)	2.66±0.84	2.63±0.85	2.79±0.74
HDL-C (mmol/L)	1.23±0.35	1.18±0.32 (75.3%)	1.49±0.36 (12.3%)
TG (mmol/L)	1.82±1.07	1.96±1.12 (67.7%)	1.17±0.37 (2.9%)
Total-C/HDL-C	4.01±1.28	4.16±1.33	3.34±0.75
Blood pressure
SBP (mm Hg)	138.4±17.1	139.5±17.2 (88.7%)	133.8±15.7 (58.9%)
DBP (mm Hg)	83.5±11.5	83.7±11.7 (77.9%)	82.7±10.3 (47.7%)

Values are presented as mean ± SD. ^aSeven individuals were not classified as MetS+ or MetS− due to missing data. ^bNumbers into parenthesis represent the percentage of individuals meeting the corresponding MetS criterion. MetS+: metabolic syndrome affected individuals; BMI: body mass index; Total-C: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides; SBP: systolic blood pressure; DBP: diastolic blood pressure.