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International Journal of Genomics
Volume 2014 (2014), Article ID 302568, 7 pages
http://dx.doi.org/10.1155/2014/302568
Research Article

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

1Division of Pain, ISSSTE Hospital, 80200 Culiacán, SIN, Mexico
2Faculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico
3Human Genetics Laboratory of the Research Unit, Faculty of Medicine, Autonomous University of Sinaloa, 80019 Culiacán, SIN, Mexico
4Division of Immunogenetics, National Institute of Medical Sciences and Nutrition, 14000 Mexico City, DF, Mexico
5Department of Immunology, National School of Biological Science, National Polytechnic Institute, 11340 Mexico City, DF, Mexico
6Division of Infectious Diseases, Boston Children’s Hospital and Harvard Medical School, Harvard University, Boston, MA 02115, USA
7Laboratory of Immunology, Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Avenida de las Américas y Universitarios s/n, Ciudad Universitaria, 80010 Culiacán, SIN, Mexico

Received 11 September 2014; Accepted 12 November 2014; Published 20 November 2014

Academic Editor: Mohamed Salem

Copyright © 2014 Salvador Cervin Serrano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD and subjects with normal lumbar-spine MRI-scans . Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% for T of rs1800587 (IL1A); 53.0% versus 58.0% for V of rs2228570 (VDR); and 18.0% versus 21.0% for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population.