A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer

Table 1

Characteristics of studies included in the meta-analysis.

First author	Year	Country	Ethnicity	Cancer type	Genotyping Methods	Case						Control						HWE
						Number	GG	GA	AA	G	A	Number	GG	GA	AA	G	A
Poole [11]	2011	Germany	Caucasian	Colorectal cancer	Mass Assay	2002	1122	743	137	2987	1017	2550	1456	925	169	3837	1263	0.18
Kallel [12]	2009	Tunisia	Arab	Breast cancer	PCR-RFLP	148	90	46	12	226	70	303	174	103	26	451	155	0.07
Wu [13]	2013	China	Asian	Hepatocellular carcinoma	TaqMan	402	84	205	113	373	431	643	157	316	170	630	656	0.69
Zhang [14]	2013	China	Asian	Gastric cancer	PCR-LDR	387	75	187	109	337	405	392	65	205	116	437	335	0.12
Choi [15]	2007	South Korea	Asian	Lung cancer	PCR-RFLP	582	206	279	97	691	473	582	215	268	99	698	466	0.32
Torres-Jasso [16]	2013	Mexico	Mexican	Gastric cancer	PCR-RFLP	72	31	33	8	95	49	100	49	43	8	141	59	0.94
Xie [17]	2012	China	Asian	Hepatocellular carcinoma	MALDI-TOF	311	69	130	112	268	354	311	55	144	112	254	368	0.46
Martinelli [18]	2011	Italy	Caucasian	Colorectal cancer	PCR-RFLP	70	36	23	11	95	45	72	24	38	10	86	58	0.47
Rebaï [19]	2009	Tunisia	Arab	Thyroid cancer	PCR-RFLP	106	59	41	6	159	53	302	174	98	30	446	158	0.06
Abdraboh [20]	2013	Egypt	Caucasian	Breast cancer	PCR-RFLP	64	11	50	3	72	56	86	48	36	2	132	40	0.14
Mustafa [21]	2013	Syria	Arab	Colorectal cancer	PCR-RFLP	47	19	27	1	65	29	48	20	21	7	61	35	0.76
Sobti [22]	2012	India	Indian	Breast cancer	PCR-RFLP	150	53	85	12	191	109	150	64	73	13	201	99	0.27
Hong [23]	2009	China	Asian	Breast cancer	TaqMan	2987	747	1460	780	2954	3020	2916	630	1516	770	2776	3056	0.19