A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer
Table 2
Meta-analysis of the R521K polymorphism with risk of cancer.
AA versus GG
GA versus GG
AA versus GA + GG
AA + GA versus GG
A versus G
OR (95% CI)
(%)
OR (95% CI)
(%)
OR (95% CI)
(%)
OR (95% CI)
(%)
OR (95% CI)
(%)
Overall
13
0.85 [0.74, 0.99]
0.25
19
0.12
1.04 [0.87, 1.25]
74
0.67
0.99 [0.91, 1.08]
0.84
0
0.92
1.02 [0.86, 1.21]
0.0001
69
0.60
1.06 [0.95, 1.18]
0.0001
69
0.28
Cancer type
Breast cancer
4
0.94 [0.65, 1.38]
0.22
32
0.77
1.41 [0.77, 2.60]
89
0.27
0.99 [0.88, 1.10]
0.88
0
0.80
1.40 [0.78, 2.50]
89
0.26
1.18 [0.84, 1.64]
0.0007
83
0.33
Colorectal cancer
3
0.81 [0.42, 1.58]
0.18
42
0.98
0.85 [0.47, 1.55]
0.03
70
0.60
1.04 [0.83, 1.31]
0.97
0
0.72
0.85 [0.52, 1.38]
0.08
61
0.51
0.92 [0.72, 1.18]
0.21
35
0.78
Gastric cancer
2
0.94 [0.55, 1.59]
0.26
21
0.56
0.91 [0.61, 1.34]
0.26
21
0.48
0.97 [0.72, 1.30]
0.43
0
0.82
0.90 [0.52, 1.56]
0.11
60
0.71
1.43 [1.19, 1.72]
0.49
0
0.001
Hepatocellular carcinoma
2
1.01 [0.66, 1.57]
0.12
58
0.95
0.95 [0.57, 1.59]
0.05
73
0.85
1.05 [0.85, 1.30]
0.70
0
0.65
0.98 [0.61, 1.57]
0.06
73
0.92
1.03 [0.90, 1.18]
0.18
45
0.68
Other cancers
2
0.93 [0.61, 1.40]
0.27
17
0.75
1.12 [0.89, 1.40]
0.64
0
0.33
0.91 [0.68, 1.21]
0.23
30
0.52
1.07 [0.87, 1.32]
0.96
0
0.52
1.01 [0.87, 1.17]
0.67
0
0.90
Ethnicity
Arab
3
0.65 [0.34, 1.26]
0.29
19
0.13
1.05 [0.78, 1.42]
0.45
0
0.74
0.58 [0.34, 1.01]
0.91
0
0.06
0.97 [0.73, 1.28]
0.76
0
0.83
0.90 [0.72, 1.12]
0.87
0
0.35
Asian
5
0.91 [0.79, 1.05]
0.32
15
0.20
0.91 [0.76, 1.10]
0.06
57
0.35
0.99 [0.90, 1.09]
0.96
0
0.85
0.91 [0.76, 1.09]
0.04
60
0.30
1.06 [0.91, 1.25]
0.0004
80
0.44
Caucasian
3
1.18 [0.57, 2.45]
0.13
50
0.66
1.34 [0.43, 4.19]
92
0.62
1.05 [0.84, 1.32]
0.75
0
0.65
1.40 [0.48, 4.09]
92
0.54
1.21 [0.68, 2.15]
0.0005
87
0.51
Other ethnicities
2
1.15 [0.59, 2.27]
0.46
0
0.68
1.33 [0.91, 1.96]
0.72
0
0.14
1.09 [0.57, 2.07]
0.50
0
0.79
1.33 [0.92, 1.92]
0.86
0
0.13
1.18 [0.90, 1.55]
0.83
0
0.22
: number of studies, OR (95% CI): odds ratio (95% confidence interval), and : values of -test for heterogeneity test. Random effects model was used when or %; otherwise fixed effect model was used.
