High Expression of Polo-Like Kinase 1 Is Associated with Early Development of Hepatocellular Carcinoma

Table 1

The relationship of PLK1 expression and HCC clinicopathological variables.

Clinicopathological factors	𝑛	PLK1 expression			Positive incidence
		None	Low	High
Age (yr)
>50	39	8	12	19	78.5%
≤50	28	8	9	11	71.4%
Clinical stage
Phases I + II	46	12	14	20	73.9%
Phase III	21	4	7	10	81.0%
Tumor nodule
1	48	12	12	24	75.0%
≥2	19	4	9	6	78.9%
Tumor diameter
>5 cm	44	12	14	18	72.7%
≤5 cm	23	4	7	12	82.6%
Lymphatic metastasis
Yes	5	2	2	1	60.0%
No	62	14	19	29	77.4%
Extrahepatic metastasis
Yes	10	4	3	3	60.0%
No	57	12	18	27	78.9%
Capsule invasion
Yes	27	10	8	9	63.0%**
No	40	6	13	21	85.0%
Tumor thrombi in portal vein
Yes	15	4	5	6	73.3%
No	52	12	16	24	76.9%
Histological differentiation (Sugihara grading criteria)
Well-	26	1	7	18	96.2%*
Moderate/poor-	41	15	14	12	63.4%
Total	67	16	21	30	76.1%

The 𝑃 value is less than 0.01, when HCC with capsule invasion is compared with HCC without capsule invasion. The 𝑃 value is less than 0.05, when HCC in well differentiation is compared with HCC in moderate or poor differentiation.
^∗𝑃<0.05, ^∗∗𝑃<0.01.