Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes

Table 3

KEGG enrichment analysis of genes coexpressed with MRCs.

Term	Count	Pop	𝑃 value	Genes
Parkinson’s disease	40	128	9.27𝐸−15	UQCRC2, ATP5D, NDUFB4, NDUFB6, NDUFB7, UBE2G1, CYC1, NDUFAB1, PINK1 , ATP5G2, UQCRFS1, COX5A, NDUFB1, NDUFB2, UQCR11, ATP5O, ATP5H, NDUFS1, ATP6, NDUFA5, NDUFA2, COX7A1, SLC25A4, NDUFA6, CYCS, NDUFC2, ATP5F1, COX4I1, NDUFC1, NDUFA10, VDAC2, VDAC3, VDAC1, SDHA, NDUFV3, PPID, NDUFV2, SDHD, COX6A2, ATP5A1
Hypertrophic cardiomyopathy (HCM)	32	85	2.33𝐸−14	PRKAG3, MYL2, TNNC1, MYL3, PRKAG1, MYBPC3, PRKAG2, CACNB1, DAG1, TPM2, TTN, TPM3, DES, DMD, ITGB6, PRKAA2, ACTC1, CACNG6, PRKAB2, MYH7, MYH6, CACNG1, TNNI3, CACNA1S , TNNT2, ATP2A2, SGCG, ITGA7, SGCD, RYR2, SGCA, SGCB
Alzheimer’s disease	41	163	1.03𝐸−11	UQCRC2, ATP5D, NDUFB4, NDUFB6, NDUFB7, CYC1, NDUFAB1, ATP5G2, UQCRFS1, COX5A, NDUFB1, NDUFB2, UQCR11, CALML6 , ATP5O, ATP5H, GAPDH, NDUFS1, ATP6, NDUFA5, LPL , NDUFA2, COX7A1, NDUFA6, CYCS, NDUFC2, ATP5F1, COX4I1, BAD , NDUFC1, NDUFA10, CACNA1S, SDHA, NDUFV3, ATP2A2, ATP2A1, NDUFV2, SDHD, PSEN2 , COX6A2, ATP5A1
Dilated cardiomyopathy	30	92	1.15𝐸−11	MYL2, TNNC1, MYL3, MYBPC3, CACNB1, DAG1, TTN, TPM2, TPM3, DES, DMD, ITGB6, PRKACA, ACTC1, CACNG6, MYH7, MYH6, CACNG1, TNNI3, CACNA1S, TNNT2, ADCY9, ATP2A2, SGCG, PLN, ITGA7, SGCD, RYR2, SGCA, SGCB
Huntington’s disease	43	180	1.80𝐸−11	UQCRC2, ATP5D, NDUFB4, POLR2E , NDUFB6, CLTB , NDUFB7, POLR2LL , CYC1, NDUFAB1, ATP5G2, UQCRFS1, COX5A, NDUFB1, NDUFB2, UQCR11, ATP5O, ATP5H, NDUFS1, ATP6, NDUFA5, NDUFA2, COX7A1, SLC25A4, NDUFA6, CYCS, ATP5F1, NDUFC2, COX4I1, NDUFC1, NDUFA10, VDAC2, VDAC3, PPARGC1A , VDAC1, SDHA, NDUFV3, PPID, NDUFV2, SDHD, COX6A2, ATP5A1, CLTCL1