Associations of CTLA4 Gene Polymorphisms with Graves’ Ophthalmopathy: A Meta-Analysis

Table 1

General characteristics of the selected studies in the meta-analysis.

Ethnic	Country	SNP genotyping	Grouping method		Eligible subjects		First author (year) [reference]
			GO	Non-GO	GO	Non-GO
European	USA	RFLP	NOSPEC3–6	No clinical feature	85	52	Villanueva (2000) [16]
	UK	RFLP	NOSPEC3–6	NOSPEC < 3	161	323	Allahabadia (2001) [17]
	Slovenia	RFLP	Clinical features	No clinical feature	33	34	Zaletel (2002) [18]
	Iran	RFLP	NOSPEC3–6	NOSPEC < 3	105	100	Esteghamati (2009) [24]
	Poland	RFLP	NOSPEC3–6	No clinical feature	95	169	Bednarczuk (2003) [19]
	UK	RFLP	NOSPEC3–6	NOSPEC < 3	124	168	Vaidya (2003) [11]
	Poland	Minisequencing	NOSPEC3–6	NOSPEC < 3	50	49	Frydecka (2004) [13]
	Italy	RFLP	NOSPEC2–6	NOSPEC < 3	90	60	Petrone (2005) [20]
Asian	China	DCFH	NOSPEC3–6	NOSPEC < 3	142	119	Han (2006) [21]
	China	RFLP	NOSPEC3–6	No clinical feature	33	56	Zhang (2006) [22]
	China	RFLP	NOSPEC2	NOSPEC3, 4	34	22	Chong (2008) [23]
	Japan	RFLP	NOSPEC3–6	No clinical feature	99	220	Bednarczuk (2003) [19]
	Korea	RFLP	Clinical feature	No clinical feature	26	47	Park (2000) [15]