Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach
Table 1
List of oppositely up- or downregulated KEGG pathways in the longissimus dorsi intramuscular adipose tissue compared to muscle and subcutaneous adipose and omental adipose tissues in Hanwoo.
KEGG ID
Pathway
Fold enrichment
Bonferroni
Upregulated
bta04510
Focal adhesion†
2.7
bta04512
ECM-receptor interaction†
3.7
bta04360
Axon guidance†
2.8
bta05200
Pathways in cancer
1.8
bta04270
Vascular smooth muscle contraction
2.4
bta04062
Chemokine signaling pathway†
2.0
bta05412
Arrhythmogenic right ventricular cardiomyopathy
2.8
bta04810
Regulation of actin cytoskeleton†
1.9
bta05414
Dilated cardiomyopathy
2.5
Downregulated
bta00190
Oxidative phosphorylation‡
6.2
bta05012
Parkinson’s disease‡
6.0
bta05016
Huntington’s disease‡
4.8
bta05010
Alzheimer’s disease‡
4.8
bta00020
Citrate cycle (TCA cycle)‡
10.5
bta03050
Proteasome‡
7.0
bta00280
Valine, leucine, and isoleucine degradation
5.9
bta00640
Propanoate metabolism
6.7
bta00071
Fatty acid degradation
5.4
bta00650
Butanoate metabolism
5.4
bta00620
Pyruvate metabolism‡
4.7
Downregulated in the muscle tissue. Upregulated in the muscle tissue.