Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach

Table 2

List of oppositely up- or downregulated KEGG pathways in the longissimus dorsi muscle tissue compared to intramuscular, subcutaneous, and omental adipose tissues in Hanwoo.

	KEGG ID	Pathway	Fold enrichment	Bonferroni
Upregulated	bta05012	Parkinson’s disease^†	4.2
	bta05010	Alzheimer’s disease^†	3.7
	bta00190	Oxidative phosphorylation^†	4.0
	bta05016	Huntington’s disease^†	3.4
	bta03050	Proteasome^†	5.3
	bta04260	Cardiac muscle contraction	3.7
	bta00020	Citrate cycle (TCA cycle)^†	5.1
	bta05410	Hypertrophic cardiomyopathy (HCM)	2.7
	bta05414	Dilated cardiomyopathy	2.5
	bta00230	Purine metabolism	2.0
	bta04120	Ubiquitin mediated proteolysis	2.1
	bta00620	Pyruvate metabolism^†	3.0
	bta00010	Glycolysis/gluconeogenesis	2.6
Downregulated	bta04510	Focal adhesion^‡	1.9
	bta04512	ECM-receptor interaction^‡	2.4
	bta04640	Hematopoietic cell lineage	2.3
	bta04062	Chemokine signaling pathway^‡	1.8
	bta04360	Axon guidance^‡	2.0
	bta04670	Leukocyte transendothelial migration	2.0
	bta04060	Cytokine-cytokine receptor interaction	1.7
	bta00600	Sphingolipid metabolism	2.7
	bta04514	Cell adhesion molecules (CAMs)	1.8
	bta04810	Regulation of actin cytoskeleton^‡	1.6
	bta04142	Lysosome	1.8
	bta04666	Fc gamma R-mediated phagocytosis	2.0

Downregulated in the intramuscular adipose tissue.
Upregulated in the intramuscular adipose tissue.