Comparative Analysis of Glycogene Expression in Different Mouse Tissues Using RNA-Seq Data

Table 5

Enrichment of GO terms for BvL579, BvM501, and LvM442 cluster analysis.

(a) BvL579

Cluster number	Term	P value
1	GO:0002541~activation of plasma proteins involved in acute inflammatory response	5.02E − 22
	GO:0006956~complement activation	5.02E − 22
	GO:0002526~acute inflammatory response	2.26E − 20
	GO:0006959~humoral immune response	2.25E − 19
	GO:0051604~protein maturation	3.43E − 19
	GO:0051605~protein maturation by peptide bond cleavage	3.19E − 18
	GO:0002253~activation of immune response	3.20E − 18
	GO:0016485~protein processing	6.27E − 18
	GO:0006957~complement activation, alternative pathway	8.91E − 18
	GO:0006954~inflammatory response	1.44E − 17
2	GO:0051094~positive regulation of developmental process	5.33E − 05
	GO:0042592~homeostatic process	4.25E − 04
	GO:0009611~response to wounding	7.29E − 04
	GO:0001568~blood vessel development	9.88E − 04
	GO:0001944~vasculature development	0.001101764
	GO:0050817~coagulation	0.001394123
	GO:0007596~blood coagulation	0.001394123
	GO:0007599~hemostasis	0.001452434
	GO:0050878~regulation of body fluid levels	0.002774109
	GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway	0.003100357
3	GO:0050817~coagulation	2.74E − 11
	GO:0007596~blood coagulation	2.74E − 11
	GO:0007599~hemostasis	3.08E − 11
	GO:0050878~regulation of body fluid levels	1.97E − 10
	GO:0042060~wound healing	1.26E − 09
	GO:0009611~response to wounding	5.75E − 08
	GO:0007167~enzyme linked receptor protein signaling pathway	9.33E − 08
	GO:0001568~blood vessel development	5.52E − 07
	GO:0001944~vasculature development	6.64E − 07
	GO:0001525~angiogenesis	4.71E − 05
4	GO:0022404~molting cycle process	2.16E − 04
	GO:0022405~hair cycle process	2.16E − 04
	GO:0001942~hair follicle development	2.16E − 04
	GO:0042633~hair cycle	2.42E − 04
	GO:0042303~molting cycle	2.42E − 04
	GO:0008544~epidermis development	0.003102493
	GO:0007398~ectoderm development	0.00369522
	GO:0050678~regulation of epithelial cell proliferation	0.009595347
	GO:0048732~gland development	0.01092817
	GO:0007173~epidermal growth factor receptor signaling pathway	0.025611634
5	GO:0007166~cell surface receptor linked signal transduction	1.34E − 05
	GO:0016477~cell migration	2.69E − 05
	GO:0042127~regulation of cell proliferation	3.44E − 05
	GO:0051674~localization of cell	4.88E − 05
	GO:0048870~cell motility	4.88E − 05
	GO:0006928~cell motion	6.35E − 05
	GO:0008284~positive regulation of cell proliferation	2.52E − 04
	GO:0007229~integrin-mediated signaling pathway	4.87E − 04
	GO:0040007~growth	6.74E − 04
	GO:0007507~heart development	0.001229375
6	GO:0055088~lipid homeostasis	2.16E − 16
	GO:0042632~cholesterol homeostasis	2.64E − 15
	GO:0055092~sterol homeostasis	2.64E − 15
	GO:0030301~cholesterol transport	3.97E − 13
	GO:0015918~sterol transport	3.97E − 13
	GO:0033344~cholesterol efflux	7.23E − 13
	GO:0006869~lipid transport	3.89E − 12
	GO:0008203~cholesterol metabolic process	4.74E − 12
	GO:0010876~lipid localization	8.01E − 12
	GO:0016125~sterol metabolic process	1.02E − 11
7	GO:0009611~response to wounding	3.88E − 07
	GO:0007596~blood coagulation	2.94E − 06
	GO:0050817~coagulation	2.94E − 06
	GO:0007599~hemostasis	3.11E − 06
	GO:0050878~regulation of body fluid levels	7.69E − 06
	GO:0042060~wound healing	1.91E − 05
	GO:0051818~disruption of cells of other organism during symbiotic interaction	3.08E − 05
	GO:0051851~modification by host of symbiont morphology or physiology	3.08E − 05
	GO:0051883~killing of cells in other organism during symbiotic interaction	3.08E − 05
	GO:0031640~killing of cells of another organism	4.30E − 05
8	GO:0006689~ganglioside catabolic process	5.11E − 06
	GO:0046479~glycosphingolipid catabolic process	1.79E − 05
	GO:0019377~glycolipid catabolic process	1.79E − 05
	GO:0001573~ganglioside metabolic process	2.38E − 05
	GO:0046466~membrane lipid catabolic process	1.15E − 04
	GO:0030149~sphingolipid catabolic process	1.15E − 04
	GO:0019915~lipid storage	1.29E − 04
	GO:0006687~glycosphingolipid metabolic process	2.73E − 04
	GO:0006664~glycolipid metabolic process	3.90E − 04
	GO:0050885~neuromuscular process controlling balance	4.98E − 04

(b) BvM501

Cluster number	Term	P value
1	GO:0040008~regulation of growth	3.73E − 08
	GO:0051604~protein maturation	7.27E − 08
	GO:0001558~regulation of cell growth	1.29E − 06
	GO:0016485~protein processing	2.32E − 05
	GO:0016044~membrane organization	7.38E − 05
	GO:0016064~immunoglobulin mediated immune response	9.61E − 05
	GO:0051605~protein maturation by peptide bond cleavage	1.09E − 04
	GO:0019724~B cell mediated immunity	1.09E − 04
	GO:0002684~positive regulation of immune system process	1.29E − 04
	GO:0006958~complement activation, classical pathway	2.00E − 04
2	GO:0009100~glycoprotein metabolic process	2.16E − 06
	GO:0050654~chondroitin sulfate proteoglycan metabolic process	9.34E − 06
	GO:0006029~proteoglycan metabolic process	8.82E − 05
	GO:0048754~branching morphogenesis of a tube	1.02E − 04
	GO:0019800~peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	1.89E − 04
	GO:0001763~morphogenesis of a branching structure	3.20E − 04
	GO:0001568~blood vessel development	4.29E − 04
	GO:0001944~vasculature development	4.79E − 04
	GO:0030204~chondroitin sulfate metabolic process	6.09E − 04
	GO:0006813~potassium ion transport	8.13E − 04
3	GO:0001501~skeletal system development	1.07E − 16
	GO:0030509~BMP signaling pathway	6.34E − 14
	GO:0001503~ossification	4.02E − 12
	GO:0060348~bone development	7.43E − 12
	GO:0030500~regulation of bone mineralization	6.08E − 11
	GO:0007178~transmembrane receptor protein serine/threonine kinase signaling pathway	7.75E − 11
	GO:0070167~regulation of biomineral formation	9.25E − 11
	GO:0007167~enzyme linked receptor protein signaling pathway	1.84E − 10
	GO:0007369~gastrulation	2.22E − 10
	GO:0051216~cartilage development	3.31E − 10
4	GO:0006928~cell motion	9.88E − 05
	GO:0016055~Wnt receptor signaling pathway	2.59E − 04
	GO:0016477~cell migration	4.37E − 04
	GO:0048870~cell motility	7.09E − 04
	GO:0051674~localization of cell	7.09E − 04
	GO:0007160~cell-matrix adhesion	0.001189285
	GO:0009100~glycoprotein metabolic process	0.001250564
	GO:0031589~cell-substrate adhesion	0.001570006
	GO:0007155~cell adhesion	0.005368157
	GO:0022610~biological adhesion	0.005405426
5	GO:0006689~ganglioside catabolic process	1.66E − 05
	GO:0019377~glycolipid catabolic process	5.78E − 05
	GO:0046479~glycosphingolipid catabolic process	5.78E − 05
	GO:0001573~ganglioside metabolic process	7.69E − 05
	GO:0009611~response to wounding	2.01E − 04
	GO:0046466~membrane lipid catabolic process	3.70E − 04
	GO:0030149~sphingolipid catabolic process	3.70E − 04
	GO:0019915~lipid storage	4.16E − 04
	GO:0006687~glycosphingolipid metabolic process	8.77E − 04
	GO:0009311~oligosaccharide metabolic process	0.001247784
6	GO:0042592~homeostatic process	6.03E − 06
	GO:0043270~positive regulation of ion transport	0.001725638
	GO:0051270~regulation of cell motion	0.002725255
	GO:0048771~tissue remodeling	0.003048492
	GO:0001894~tissue homeostasis	0.003842174
	GO:0051050~positive regulation of transport	0.004095371
	GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway	0.004147057
	GO:0032869~cellular response to insulin stimulus	0.004461779
	GO:0042127~regulation of cell proliferation	0.004903945
	GO:0010765~positive regulation of sodium ion transport	0.005901212
7	GO:0001666~response to hypoxia	0.006023043
	GO:0070482~response to oxygen levels	0.006648281
	GO:0016042~lipid catabolic process	0.009864913
	GO:0006644~phospholipid metabolic process	0.011805904
	GO:0019637~organophosphate metabolic process	0.013020542
	GO:0006916~anti-apoptosis	0.013774773
	GO:0043066~negative regulation of apoptosis	0.037899056
	GO:0043069~negative regulation of programmed cell death	0.038883095
	GO:0060548~negative regulation of cell death	0.03908111
8	NA	NA
9	GO:0007160~cell-matrix adhesion	0.001495186
	GO:0031589~cell-substrate adhesion	0.001809131
	GO:0051085~chaperone mediated protein folding requiring cofactor	0.006635187
	GO:0051084~“de novo” posttranslational protein folding	0.008618097
	GO:0007155~cell adhesion	0.00916406
	GO:0022610~biological adhesion	0.009200307
	GO:0050982~detection of mechanical stimulus	0.010597488
	GO:0006458~“de novo” protein folding	0.010597488
	GO:0007259~JAK-STAT cascade	0.025656487
	GO:0030001~metal ion transport	0.036163834
	GO:0030001~metal ion transport	0.036163834

(c) LvM442

Cluster number	Term	P value
1	GO:0001568~blood vessel development	1.06E − 18
	GO:0001944~vasculature development	1.64E − 18
	GO:0048514~blood vessel morphogenesis	8.45E − 16
	GO:0001525~angiogenesis	3.48E − 12
	GO:0048754~branching morphogenesis of a tube	9.17E − 11
	GO:0007167~enzyme linked receptor protein signaling pathway	5.50E − 10
	GO:0035239~tube morphogenesis	1.14E − 09
	GO:0001763~morphogenesis of a branching structure	1.32E − 09
	GO:0035295~tube development	5.53E − 09
	GO:0001569~patterning of blood vessels	3.29E − 08
2	GO:0040008~regulation of growth	4.27E − 07
	GO:0009611~response to wounding	4.18E − 06
	GO:0006954~inflammatory response	3.42E − 05
	GO:0032101~regulation of response to external stimulus	1.89E − 04
	GO:0048585~negative regulation of response to stimulus	7.82E − 04
	GO:0006952~defense response	0.001399518
	GO:0001558~regulation of cell growth	0.002134607
	GO:0050867~positive regulation of cell activation	0.002784166
	GO:0032102~negative regulation of response to external stimulus	0.004518678
	GO:0008283~cell proliferation	0.004842417
3	GO:0007160~cell-matrix adhesion	7.84E − 05
	GO:0031589~cell-substrate adhesion	1.14E − 04
	GO:0044242~cellular lipid catabolic process	9.80E − 04
	GO:0016042~lipid catabolic process	9.93E − 04
	GO:0051346~negative regulation of hydrolase activity	0.006807864
	GO:0008218~bioluminescence	0.007742186
	GO:0018401~peptidyl-proline hydroxylation to 4-hydroxy-L-proline	0.007742186
	GO:0019471~4-hydroxyproline metabolic process	0.007742186
	GO:0009101~glycoprotein biosynthetic process	0.007780584
	GO:0007155~cell adhesion	0.00843311
4	GO:0001501~skeletal system development	7.15E − 04
	GO:0006955~immune response	0.011579
	GO:0051085~chaperone mediated protein folding requiring cofactor	0.013230724
	GO:0051084~“de novo” posttranslational protein folding	0.01716759
	GO:0045453~bone resorption	0.019783921
	GO:0006458~“de novo” protein folding	0.021089619
	GO:0046849~bone remodeling	0.027593503
	GO:0006952~defense response	0.045862312
5	GO:0001916~positive regulation of T cell mediated cytotoxicity	4.08E − 05
	GO:0001914~regulation of T cell mediated cytotoxicity	6.22E − 05
	GO:0002711~positive regulation of T cell mediated immunity	8.81E − 05
	GO:0002474~antigen processing and presentation of peptide antigen via MHC class I	1.53E − 04
	GO:0002709~regulation of T cell mediated immunity	1.72E − 04
	GO:0031343~positive regulation of cell killing	2.84E − 04
	GO:0001912~positive regulation of leukocyte mediated cytotoxicity	2.84E − 04
	GO:0001910~regulation of leukocyte mediated cytotoxicity	4.86E − 04
	GO:0031341~regulation of cell killing	4.86E − 04
	GO:0002821~positive regulation of adaptive immune response	6.25E − 04
6	GO:0002526~acute inflammatory response	4.67E − 14
	GO:0045087~innate immune response	4.65E − 13
	GO:0002684~positive regulation of immune system process	1.53E − 12
	GO:0050778~positive regulation of immune response	3.29E − 12
	GO:0006954~inflammatory response	3.41E − 12
	GO:0002541~activation of plasma proteins involved in acute inflammatory response	4.05E − 12
	GO:0006956~complement activation	4.05E − 12
	GO:0048584~positive regulation of response to stimulus	4.13E − 11
	GO:0006952~defense response	4.75E − 11
	GO:0006959~humoral immune response	5.29E − 11
7	GO:0009611~response to wounding	2.97E − 06
	GO:0006958~complement activation, classical pathway	7.07E − 06
	GO:0002526~acute inflammatory response	7.33E − 06
	GO:0002455~humoral immune response mediated by circulating immunoglobulin	8.69E − 06
	GO:0006956~complement activation	2.20E − 05
	GO:0002541~activation of plasma proteins involved in acute inflammatory response	2.36E − 05
	GO:0016064~immunoglobulin mediated immune response	4.70E − 05
	GO:0019724~B cell mediated immunity	5.25E − 05
	GO:0002449~lymphocyte mediated immunity	1.02E − 04
	GO:0002250~adaptive immune response	1.36E − 04
8	GO:0051450~myoblast proliferation	0.002206368
	GO:0048012~hepatocyte growth factor receptor signaling pathway	0.002206368
	GO:0060665~regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	0.003674845
	GO:0060638~mesenchymal-epithelial cell signaling	0.004408354
	GO:0060693~regulation of branching involved in salivary gland morphogenesis	0.006605966
	GO:0060688~regulation of morphogenesis of a branching structure	0.018252999
	GO:0001889~liver development	0.031208893
	GO:0000187~activation of MAPK activity	0.036205594
	GO:0043406~positive regulation of MAP kinase activity	0.042595839