Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain

Figure 1

Phylogenetic analysis of the FMDV genome sequences. Phylogenetic tree was constructed by the neighbor-joining method by using MEGA 3.1, and bootstrap values were determined by 1,000 replicates. The GenBank accession numbers of 16 reference strains are listed as follows. O Taiwan/97(AY593835), O/Manisa-iso87(AY593823), A12 Valle strain-119(AY593752), A22 Turkey/65-iso66(AY593765), C1/C-s8cl(AJ133357), C3/Arg/85(AJ007347), SAT1 BOT/1/68(AY593845), SAT2/KEN/57(AY251473), SAT3/4 BEC 1/65(AY593853), Asia1 PAK/iso3(AY593795), Asia1 IND 13/91(DQ989312), Asia1 IND321/01(AY687333), Asia1/Shamir/89(JF739177), Asia1/MOG/05(EF614458), Asia1/JS/CHA/05(EF149009), Asia1/IND 63/72(AY304994), YNBS/58(AY390432), and ZB/CHA/58(att)(DQ533483).