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International Journal of Genomics
Volume 2014, Article ID 978609, 8 pages
http://dx.doi.org/10.1155/2014/978609
Research Article

Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain

1Yunnan Tropical and Subtropical Animal Virus Disease Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming 650224, China
2Yunnan Provincial Research Center for Veterinary Biological Products, Baoshan 678000, China

Received 27 May 2014; Revised 18 September 2014; Accepted 22 September 2014; Published 19 October 2014

Academic Editor: Graziano Pesole

Copyright © 2014 Aiguo Xin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. J. Grubman and B. Baxt, “Foot-and-mouth disease,” Clinical Microbiology Reviews, vol. 17, no. 2, pp. 465–493, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Domingo, C. Escarmís, E. Baranowski et al., “Evolution of foot-and-mouth disease virus,” Virus Research, vol. 91, no. 1, pp. 47–63, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Parida, “Vaccination against foot-and-mouth disease virus: strategies and effectiveness,” Expert Review of Vaccines, vol. 8, no. 3, pp. 347–365, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. G. J. Belsham, “Distinctive features of foot-and-mouth disease virus, a member of the picornavirus family; aspects of virus protein synthesis, protein processing and structure,” Progress in Biophysics and Molecular Biology, vol. 60, no. 3, pp. 241–260, 1993. View at Publisher · View at Google Scholar · View at Scopus
  5. M. D. Ryan, G. J. Belsham, and A. M. Q. King, “Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing,” Virology, vol. 173, no. 1, pp. 35–45, 1989. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Du, H. Chang, G. Cong et al., “Complete nucleotide sequence of a Chinese serotype Asia1 vaccine strain of foot-and-mouth disease virus,” Virus Genes, vol. 35, no. 3, pp. 635–642, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Xin, H. Li, L. Li et al., “Genome analysis and development of infectious cDNA clone of a virulence-attenuated strain of foot-and-mouth disease virus type Asia 1 from China,” Veterinary Microbiology, vol. 138, no. 3-4, pp. 273–280, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. H. L. Bachrach, “Foot-and-mouth disease.,” Annual Review of Microbiology, vol. 22, pp. 201–244, 1968. View at Publisher · View at Google Scholar · View at Scopus
  9. J. D. Thompson, T. J. Gibson, F. Plewniak, F. Jeanmougin, and D. G. Higgins, “The CLUSTAL X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools,” Nucleic Acids Research, vol. 25, no. 24, pp. 4876–4882, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Kumar, K. Tamura, and M. Nei, “MEGA3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment,” Briefings in Bioinformatics, vol. 5, no. 2, pp. 150–163, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Martinez-Salas, J. C. Saiz, M. Dávila, G. J. Belsham, and E. Domingo, “A single nucleotide substitution in the internal ribosome entry site of foot-and-mouth disease virus leads to enhanced cap-independent translation in vivo,” Journal of Virology, vol. 67, no. 7, pp. 3748–3755, 1993. View at Google Scholar · View at Scopus
  12. X. Cao, I. E. Bergmann, and E. Beck, “Comparison of the 5′ and 3′ untranslated genomic regions of virulent and attenuated foot-and-mouth disease viruses (strains O1 Campos and C3 Resende),” Journal of General Virology, vol. 72, no. 11, pp. 2821–2825, 1991. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Serrano, M. Pulido Rodriguez, M. Saiz, and E. Martínez-Salas, “The 3′ end of the foot-and-mouth disease virus genome establishes two distinct long-range RNA-RNA interactions with the 5′ and region,” Journal of General Virology, vol. 87, no. 10, pp. 3013–3022, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Rodríguez Pulido, P. Serrano, M. Sáiz, and E. Martínez-Salas, “Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins,” Virology, vol. 364, no. 2, pp. 466–474, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. T. R. Sweeney, N. Roqué-Rosell, J. R. Birtley, R. J. Leatherbarrow, and S. Curry, “Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the β-ribbon in proteolysis,” Journal of Virology, vol. 81, no. 1, pp. 115–124, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. P. W. Mason, M. J. Grubman, and B. Baxt, “Molecular basis of pathogenesis of FMDV,” Virus Research, vol. 91, no. 1, pp. 9–32, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Paul and T. Michiels, “Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness,” Journal of General Virology, vol. 87, no. 5, pp. 1237–1246, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Tracy, N. M. Chapman, K. M. Drescher, K. Kono, and W. Tapprich, “Evolution of virulence in picornaviruses,” Current Topics in Microbiology and Immunology, vol. 299, pp. 193–209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. J. L. Whitton, C. T. Cornell, and R. Feuer, “Host and virus determinants of picornavirus pathogenesis and tropism,” Nature Reviews Microbiology, vol. 3, no. 10, pp. 765–776, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. M. E. Piccone, F. D.-S. Segundo, E. Kramer, L. L. Rodriguez, and T. de los Santos, “Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein,” Virus Research, vol. 155, no. 1, pp. 91–97, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. P. W. Mason, M. E. Piccone, T. S. McKenna, J. Chinsangaram, and M. J. Grubman, “Evaluation of a live-attenuated foot-and-mouth disease virus as a vaccine candidate,” Virology, vol. 227, no. 1, pp. 96–102, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Chinsangaram, P. W. Mason, and M. J. Grubman, “Protection of swine by live and inactivated vaccines prepared from a leader proteinase-deficient serotype A12 foot-and-mouth disease virus,” Vaccine, vol. 16, no. 16, pp. 1516–1522, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. M. J. Grubman, M. P. Moraes, F. Diaz-San Segundo, L. Pena, and T. De Los Santos, “Evading the host immune response: how foot-and-mouth disease virus has become an effective pathogen,” FEMS Immunology and Medical Microbiology, vol. 53, no. 1, pp. 8–17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. T. de Los Santos, S. de Avila Botton, R. Weiblen, and M. J. Grubman, “The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response,” Journal of Virology, vol. 80, no. 4, pp. 1906–1914, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. T. De Los Santos, F. D.-S. Segundo, J. Zhu, M. Koster, C. C. A. Dias, and M. J. Grubman, “A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function,” Journal of Virology, vol. 83, no. 4, pp. 1800–1810, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Mayer, D. Neubauer, A. T. Nchinda, R. Cencic, K. Trompf, and T. Skern, “Residue L143 of the foot-and-mouth disease virus leader proteinase is a determinant of cleavage specificity,” Journal of Virology, vol. 82, no. 9, pp. 4656–4659, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Doherty, D. Todd, N. McFerran, and E. M. Hoey, “Sequence analysis of a porcine enterovirus serotype 1 isolate: relationships with other picornaviruses,” Journal of General Virology, vol. 80, no. 8, pp. 1929–1941, 1999. View at Google Scholar · View at Scopus
  28. Y. Kaku, S. Yamada, and Y. Murakami, “Sequence determination and phylogenetic analysis of RNA-dependent RNA polymerase (RdRp) of the porcine enterovirus 1 (PEV-1) Talfan strain,” Archives of Virology, vol. 144, no. 9, pp. 1845–1852, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Carrillo, E. R. Tulman, G. Delhon et al., “Comparative genomics of foot-and-mouth disease virus,” Journal of Virology, vol. 79, no. 10, pp. 6487–6504, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. M. George, R. Venkataramanan, B. Pattnaik et al., “Sequence analysis of the RNA polymerase gene of foot-and-mouth disease virus serotype Asia 1,” Virus Genes, vol. 22, no. 1, pp. 21–26, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Zeng, H. Wang, X. Xie et al., “Ribavirin-resistant variants of foot-and-mouth disease virus: the effect of restricted quasispecies diversity on viral virulence,” Journal of Virology, vol. 88, no. 8, pp. 4008–4020, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. M. V. Borca, J. M. Pacheco, L. G. Holinka et al., “Role of arginine-56 within the structural protein VP3 of foot-and-mouth disease virus (FMDV) O1 Campos in virus virulence,” Virology, vol. 422, no. 1, pp. 37–45, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Wigdorovitz, D. M. Pérez Filgueira, N. Robertson et al., “Protection of mice against challenge with foot and mouth disease virus (FMDV) by immunization with foliar extracts from plants infected with recombinant tobacco mosaic virus expressing the FMDV structural protein VP1,” Virology, vol. 264, no. 1, pp. 85–91, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Curry, E. Fry, W. Blakemore et al., “Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus,” Journal of Virology, vol. 71, no. 12, pp. 9743–9752, 1997. View at Google Scholar · View at Scopus
  35. A. Bøtner, N. K. Kakker, C. Barbezange, S. Berryman, T. Jackson, and G. J. Belsham, “Capsid proteins from field strains of foot-and-mouth disease virus confer a pathogenic phenotype in cattle on an attenuated, cell-culture-adapted virus,” Journal of General Virology, vol. 92, no. 5, pp. 1141–1151, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. J. I. Nunez, N. Molina, E. Baranowski et al., “Guinea pig-adapted foot-and-mouth disease virus with altered receptor recognition can productively infect a natural host,” Journal of Virology, vol. 81, no. 16, pp. 8497–8506, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Gutiérrez-Rivas, M. R. Pulido, E. Baranowski, F. Sobrino, and M. Sáiz, “Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context,” Journal of General Virology, vol. 89, no. 10, pp. 2531–2539, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. M. G. Mateu, M. Luz Valero, D. Andreu, and E. Domingo, “Systematic replacement of amino acid residues within an Arg-Gly-Asp-containing loop of foot-and-mouth disease virus and effect on cell recognition,” Journal of Biological Chemistry, vol. 271, no. 22, pp. 12814–12819, 1996. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Tesar, H.-G. Berger, and O. Marquardt, “Serological probes for some foot-and-mouth disease virus nonstructural proteins,” Virus Genes, vol. 3, no. 1, pp. 29–44, 1989. View at Publisher · View at Google Scholar · View at Scopus
  40. S. U. Emerson, Y. K. Huang, H. Nguyen et al., “Identification of VP1/2A and 2C as virulence genes of hepatitis A virus and demonstration of genetic instability of 2C,” Journal of Virology, vol. 76, no. 17, pp. 8551–8559, 2002. View at Publisher · View at Google Scholar · View at Scopus
  41. J. I. Núñez, E. Baranowski, N. Molina et al., “A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig,” Journal of Virology, vol. 75, no. 8, pp. 3977–3983, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Arias, C. Perales, C. Escarmís, and E. Domingo, “Deletion mutants of VPg reveal new cytopathology determinants in a picornavirus,” PLoS ONE, vol. 5, no. 5, Article ID e10735, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Xin, L. Li, M. Zhu et al., “Whole genome sequencing of a candidate strain for FMDV vaccine: genomic structure and genetic variation,” Molecular Pathogens, vol. 2, no. 1, 2011. View at Publisher · View at Google Scholar
  44. A. T. Giraudo, E. Beck, K. Strebel et al., “Identification of a nucleotide deletion in parts of polypeptide 3A in two independent attenuated aphthovirus strains,” Virology, vol. 177, no. 2, pp. 780–783, 1990. View at Publisher · View at Google Scholar · View at Scopus
  45. C. W. Beard and P. W. Mason, “Genetic determinants of altered virulence of Taiwanese foot-and-mouth disease virus,” Journal of Virology, vol. 74, no. 2, pp. 987–991, 2000. View at Publisher · View at Google Scholar · View at Scopus
  46. J. M. Pacheco, T. M. Henry, V. K. O'Donnell, J. B. Gregory, and P. W. Mason, “Role of nonstructural proteins 3A and 3B in host range and pathogenicity of foot-and-mouth disease virus,” Journal of Virology, vol. 77, no. 24, pp. 13017–13027, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. J. M. Pacheco, D. P. Gladue, L. G. Holinka et al., “A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle,” Virology, vol. 446, no. 1-2, pp. 260–267, 2013. View at Publisher · View at Google Scholar · View at Scopus