Comprehensive Analysis of Transcriptome Sequencing Data in the Lung Tissues of COPD Subjects

Table 3

Top 20 genes differentially expressed between COPD subjects and subjects with normal lung function.

Gene symbol	Gene function	Fold change	value	value	Expression levels
					()
RAD54L2	Androgen receptor-interacting protein	0.70	1.23E − 24	2.05E − 20	4.13
UBR4	Ubiquitin protein ligase E3 component n-recognin 4	0.46	6.24E − 24	1.04E − 19	9.71
KPNA6	Karyopherin alpha 6	0.27	2.25E − 21	3.75E − 17	11.03
VPS28	Vacuolar protein	−0.51	1.11E − 20	1.86E − 16	60.90
STRA13	Stimulated by retinoic acid	−0.78	2.29E − 20	3.82E − 16	21.96
SPEN	Spen family transcriptional repressor	0.47	2.68E − 20	4.47E − 16	9.99
HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	0.42	3.73E − 20	6.22E − 16	6.05
GTF3C3	General transcription factor IIIC	0.58	6.53E − 20	1.09E − 15	9.52
TCF20	Transcription factor 20 (AR1)	0.35	7.22E − 20	1.20E − 15	6.49
MRPL21	Mitochondrial ribosomal protein L21	−0.55	1.91E − 19	3.19E − 15	22.24
COX6A1	Cytochrome c oxidase subunit VIa polypeptide 1	−0.66	2.17E − 19	3.63E − 15	237.71
ZZEF1	Zinc finger, ZZ-type with EF-hand domain 1	0.30	2.36E − 19	3.94E − 15	7.56
STX8	Syntaxin 8	−0.74	3.00E − 19	5.00E − 15	29.76
UBAP2L	Ubiquitin associated protein 2-like	0.27	3.48E − 19	5.80E − 15	29.99
TRRAP	Transformation/transcription domain-associated protein	0.40	3.63E − 19	6.05E − 15	4.96
ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4	0.47	3.74E − 19	6.24E − 15	11.88
TRIM56	Tripartite motif containing 56	0.45	4.37E − 19	7.30E − 15	10.09
NHSL2	NHS-like 2	1.21	4.88E − 19	8.14E − 15	1.44
SETD5	SET domain containing 5	0.23	5.17E − 19	8.62E − 15	16.95
PRKAR2A	Protein kinase, cAMP-dependent, regulatory, type II, alpha	0.79	5.39E − 19	8.99E − 15	8.33

FPKM: fragments per kilobase of exon per million fragments mapped.