Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data
Comparison of SNP content distributions in upstream regions of human genes encoding chromatin-modifying proteins with the distribution in the whole-genome dataset (Table 1). The 5′-regulatory regions between −600 and +100 bp around TSSs are analyzed. The dataset of chromatin-modifying proteins genes/transcripts was extracted from EntrezGene, CREMOFAC , and CR Cistrome Databases . In panel (a), the -axis denotes the SNP content, and the -axis denotes the fraction of transcripts with specific content of SNPs in their 5′-regulatory regions. Panel (b) presents the significance of the -test (-axis), which compares the SNP contents in test group with the content in the whole-genome dataset as a function of the threshold of SNP content (-axis). The -test was applied as described in Section 2.