| | Author | Polymorphism | Effect |
| | Stamer et al., 2003 [34] | CYP2D61, 3, 4, 5, 9, 10, CYP2D617, CYP2D61 × N | Poor metabolizers for CYP2D6 showed a lower response rate to tramadol analgesia for postoperative pain after abdominal surgery |
| | Wang et al., 2006 [37] | CYP2D610 C188T | This SNP reduced tramadol analgesic efficacy in a Chinese patients treated for postoperative pain after major abdominal surgery |
| | Siew et al., 2007 [35] | CYP2D61, 3, 4, 5, 9, 10, CYP2D617, CYP2D61 × N | The analgesic effects of tramadol were not measured adequately. Therefore the effect of genotype on tramadol analgesic efficacy was not demonstrated |
| | Slanar et al., 2012 [36] | CYP2D63, CYP2D64, CYP2D65, CYP2D66
CYP2D61 × N | CYP2D6 genotype did not affect tramadol analgesic efficacy in postoperative patients after knee arthroplasty |
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