Research Article

Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation

Figure 2

Significant lncRNA and coding RNA expression changes after LDIR exposure in mammary tissues of BALB/c mice. (a) Hierarchical clustering of lncRNAs (left) and coding RNAs (right) differentially expressed (fold-change 1.5; ) in mammary gland tissues of BALB/c mice at 2, 4, and 8 weeks after sham or LDIR exposure. Increased expression indicated in red and decreased expression in green. (b) Comparison of genes differentially expressed after low-dose radiation at each timepoint with a gene signature containing genes whose expression significantly changes in the mammary gland across the female estrous cycle. (c) The most significant gene interaction networks of estrous cycle independent genes differentially expressed after LDIR at 2, 4, and 8 weeks after exposure (see Figure S3 for annotation of molecular shapes used in the networks).