Table of Contents Author Guidelines Submit a Manuscript
International Journal of Genomics
Volume 2015, Article ID 638032, 7 pages
http://dx.doi.org/10.1155/2015/638032
Research Article

First Genomic Analysis of Dendritic Cells from Lung and Draining Lymph Nodes in Murine Asthma

1Institute of Anatomy and Cell Biology, Saarland University, Campus Homburg, Kirrberger Straße 100, 66424 Homburg, Germany
2Institute of Pharmacology, Medical School of Hannover, Carl-Neuberg-Straße 1, 30625 Hannover, Germany
3Infection Immunology Group, Institute of Medical Microbiology, Infection Control and Prevention, Otto-von-Guericke University Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany
4Department of Experimental Pneumology, Saarland University, Campus Homburg, Kirrberger Straße 100, 66424 Homburg, Germany
5Immune Regulation Group, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany

Received 16 November 2014; Revised 9 February 2015; Accepted 9 February 2015

Academic Editor: Giuliana Napolitano

Copyright © 2015 Thomas Tschernig et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Deckers, F. Branco Madeira, and H. Hammad, “Innate immune cells in asthma,” Trends in Immunology, vol. 34, no. 11, pp. 540–547, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. M. J. van Helden and B. N. Lambrecht, “Dendritic cells in asthma,” Current Opinion in Immunology, vol. 25, no. 6, pp. 745–754, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Merad, P. Sathe, J. Helft, J. Miller, and A. Mortha, “The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting,” Annual Review of Immunology, vol. 31, pp. 563–604, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Hartwig, H. Constabel, D. Neumann, H. Gerd Hoymann, T. Tschernig, and G. M. N. Behrens, “Impact of boostering for the strength of asthma parameters and dendritic cell numbers in a C57BL/6 model of allergic airway inflammation,” Experimental and Toxicologic Pathology, vol. 60, no. 6, pp. 425–434, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. B. T. Edelson, K. C. Wumesh, R. Juang et al., “Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells,” Journal of Experimental Medicine, vol. 207, no. 4, pp. 823–836, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. A. Villadangos and W. R. Heath, “Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm,” Seminars in Immunology, vol. 17, no. 4, pp. 262–272, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Y. Liu, P. Lu, L. Z. Hu et al., “CD8α DC is the major DC subset which mediates inhibition of allergic responses by Schistosoma infection,” Parasite Immunology, vol. 36, no. 12, pp. 647–657, 2014. View at Publisher · View at Google Scholar
  8. X. Gao, H. Bai, J. Cheng et al., “CD8α+ and CD8α- DC subsets from BCG-infected mice inhibit allergic Th2-cell responses by enhancing Th1-cell and Treg-cell activity respectively,” European Journal of Immunology, vol. 42, no. 1, pp. 165–175, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. E. L. Gautiar, T. Shay, J. Miller et al., “Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages,” Nature Immunology, vol. 13, no. 11, pp. 1118–1128, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. E. di Valentin, C. Crahay, N. Garbacki et al., “New asthma biomarkers: lessons from murine models of acute and chronic asthma,” The American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 296, no. 2, pp. L185–L197, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. S.-C. Hsu, C.-H. Chen, S.-H. Tsai et al., “Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells,” Journal of Biological Chemistry, vol. 285, no. 11, pp. 7903–7910, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Furuhashi and G. S. Hotamisligil, “Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets,” Nature Reviews Drug Discovery, vol. 7, no. 6, pp. 489–503, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. M. S. Rolph, T. R. Young, B. O. V. Shum et al., “Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2,” Journal of Immunology, vol. 177, no. 11, pp. 7794–7801, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. H. El-nour, L. Lundeberg, A. Boman, D. Abramowski, M. Holst, and K. Nordlind, “The expression and functional significance of the serotonin2C receptor in murine contact allergy,” Experimental Dermatology, vol. 16, no. 8, pp. 644–650, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Matsui, J. E. Connolly, M. Michnevitz et al., “CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions,” Journal of Immunology, vol. 182, no. 11, pp. 6815–6823, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. J.-F. Lauzon-Joset, A. Langlois, L. J. A. Lai et al., “Lung CD200R activation abrogates airway hyperresponsiveness in experimental asthma,” American Journal of Respiratory Cell and Molecular Biology, 2015. View at Publisher · View at Google Scholar
  17. T. Dorner, A. Shock, and K. G. C. Smith, “CD22 and autoimmune disease,” International Reviews of Immunology, vol. 31, no. 5, pp. 363–378, 2012. View at Publisher · View at Google Scholar
  18. E. Z. Reineks, E. S. Osei, A. Rosenberg, J. Auletta, and H. J. Meyerson, “CD22 expression on blastic plasmacytoid dendritic cell neoplasms and reactivity of anti-CD22 antibodies to peripheral blood dendritic cells,” Cytometry Part B—Clinical Cytometry, vol. 76, no. 4, pp. 237–248, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. G. M. Del Hoyo, P. Martín, C. F. Arias, A. R. Marín, and C. Ardavín, “CD8alpha+ dendritic cells originate from the CD8alpha dendritic cell subset by a maturation process involving CD8alpha, DEC-205, and CD24 up-regulation,” Blood, vol. 99, no. 3, pp. 999–1004, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. G.-Y. Chen, J. Tang, P. Zheng, and Y. Liu, “CD24 and siglec-10 selectively repress tissue damage-induced immune responses,” Science, vol. 323, no. 5922, pp. 1722–1725, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. V. Provost, M.-C. Larose, A. Langlois, M. Rola-Pleszczynski, N. Flamand, and M. Laviolette, “CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2,” Journal of Leukocyte Biology, vol. 94, no. 2, pp. 213–222, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. D. G. Gilbertson, M. E. Duff, J. W. West et al., “Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor,” The Journal of Biological Chemistry, vol. 276, no. 29, pp. 27406–27414, 2001. View at Publisher · View at Google Scholar · View at Scopus