First Genomic Analysis of Dendritic Cells from Lung and Draining Lymph Nodes in Murine Asthma

Table 1

KEGG pathway enrichment of 1607 regulated transcripts in CD8⁻ lung DCs.

KEGG pathway	KEGG pathway; ID	Total number of genes in pathway	Number of genes found	% genes found	Bonferroni corrected term-enrichment; value
Lysosome	4142	123	29	23.6	1.7E − 07
Chemokine signaling pathway	4062	185	29	15.7	1.7E − 03
Peroxisome	4146	79	17	21.5	1.8E − 03
PPAR signaling pathway	3320	81	17	21.0	2.5E − 03
Cytokine-cytokine receptor interaction	4060	248	34	13.7	5.7E − 03
Fc gamma R-mediated phagocytosis	4666	92	17	18.5	1.4E − 02
Toll-like receptor signaling pathway	4620	101	18	17.8	1.4E − 02
Hematopoietic cell lineage	4640	84	16	19.0	1.5E − 02
B cell receptor signaling pathway	4662	78	15	19.2	2.2E − 02
Phagosome	4145	177	25	14.1	3.6E − 02
Focal adhesion	4510	199	27	13.6	4.1E − 02

Transcripts that are found to be differentially regulated in CD8⁻ lung DCs from asthmatic-like versus healthy control mice were analyzed for statistical overrepresentation in KEGG pathway annotations using a one-sided hypergeometric test and Bonferroni value correction. Only KEGG pathways with a value <0.05 were considered to be overrepresented.