Research Article
Transcriptome Analysis of Bovine Ovarian Follicles at Predeviation and Onset of Deviation Stages of a Follicular Wave
Table 5
Differentially expressed genes between ODF1 and PDF1 with known or predicted roles in follicular development.
| | Gene symbol | Fold change | FDR corrected value | Up- or downregulation in ODF1/PDF1 | Gene product functions |
| | PPM1K | 3.18 | 2.52 × 10−7 | Upregulation | Cellular survival and development | | BEX2 | 3.75 | | Upregulation | Mitochondrial apoptosis | | CYP19A1 | 3.02 | | Upregulation | Estrogen biosynthesis | | PRSS23 | 2.67 | 2.74 × 10−8 | Upregulation | Follicular atresia | | GREB1 | 2.27 | 1.30 × 10−2 | Upregulation | Estrogen-stimulated cell proliferation | | SERPINE2 | 1.66 | | Upregulation | Serine protease inhibitor | | INHBA | 1.65 | | Upregulation | Regulate gonadal stromal cell proliferation | | CYP11A1 | 1.60 | | Upregulation | Cholesterol to pregnenolone | | INHA | 1.55 | | Upregulation | Gonadal hormone secretion | | TNFAIP6 | 4.26 | 1.06 × 10−3 | Upregulation | Cell-cell and cell-matrix interactions | | OPTN | 1.55 | 5.92 × 10−3 | Upregulation | Affect cell death | | PRSS35 | −2.38 | 1.21 × 10−5 | Downregulation | Ovulation and CL formation and regression | | APOA1 | −1.87 | 1.07 × 10−2 | Downregulation | Activates spermatozoa motility | | GSTA5 | −1.69 | 4.93 × 10−2 | Downregulation | Glutathione transferase |
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