Transcriptome Analysis of Bovine Ovarian Follicles at Predeviation and Onset of Deviation Stages of a Follicular Wave
Table 5
Differentially expressed genes between ODF1 and PDF1 with known or predicted roles in follicular development.
Gene symbol
Fold change
FDR corrected value
Up- or downregulation in ODF1/PDF1
Gene product functions
PPM1K
3.18
2.52 × 10−7
Upregulation
Cellular survival and development
BEX2
3.75
Upregulation
Mitochondrial apoptosis
CYP19A1
3.02
Upregulation
Estrogen biosynthesis
PRSS23
2.67
2.74 × 10−8
Upregulation
Follicular atresia
GREB1
2.27
1.30 × 10−2
Upregulation
Estrogen-stimulated cell proliferation
SERPINE2
1.66
Upregulation
Serine protease inhibitor
INHBA
1.65
Upregulation
Regulate gonadal stromal cell proliferation
CYP11A1
1.60
Upregulation
Cholesterol to pregnenolone
INHA
1.55
Upregulation
Gonadal hormone secretion
TNFAIP6
4.26
1.06 × 10−3
Upregulation
Cell-cell and cell-matrix interactions
OPTN
1.55
5.92 × 10−3
Upregulation
Affect cell death
PRSS35
−2.38
1.21 × 10−5
Downregulation
Ovulation and CL formation and regression
APOA1
−1.87
1.07 × 10−2
Downregulation
Activates spermatozoa motility
GSTA5
−1.69
4.93 × 10−2
Downregulation
Glutathione transferase
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