Table of Contents Author Guidelines Submit a Manuscript
International Journal of Genomics
Volume 2016, Article ID 7862962, 7 pages
http://dx.doi.org/10.1155/2016/7862962
Research Article

Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine

1Division of Rheumatology, Medical University of South Carolina, Charleston, SC 29425, USA
2Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
3Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
4Biogen Idec, Cambridge, MA 02142, USA
5Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA

Received 13 May 2016; Accepted 20 July 2016

Academic Editor: Brian Wigdahl

Copyright © 2016 Eric Zollars et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus—specifically lupus nephritis.